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首页> 外文期刊>Journal of biochemical and molecular toxicology >A review on the physiological and pathophysiological role of endothelial glycocalyx
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A review on the physiological and pathophysiological role of endothelial glycocalyx

机译：内皮甘油癌的生理和病理生理作用综述

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摘要

The glycocalyx is a gel-like layer covering the luminal surface of vascular endothelial cells. It comprises of membrane-attached proteoglycans, glycosaminoglycan chains, glycopro-teins, and adherent plasma proteins. The glycocalyx maintains homeostasis of the vas-culature, which includes controlling vascular permeability and microvascular tone, preventing microvascular thrombosis, and regulating leukocyte adhesion. In the past decades, the number of studies on endothelial glycocalyx has steadily grown. Glycocalyx emerged as an essential part of blood vessels involved in multiple physiological functions. Damage to glycocalyx is associated with many types of diseases. The structure and physiology and pathophysiology of the glycocalyx, as well as the clinical effects of glycocalyx degradation, are addressed throughout this study. We strive in particular to define therapeutic approaches for the survival or reparation of the glycocalyx.
机译：糖萼是覆盖血管内皮细胞管腔表面的凝胶状层。它由膜连接的蛋白多糖、糖胺聚糖链、糖蛋白和粘附的血浆蛋白组成。糖萼维持血管的内环境稳定，包括控制血管通透性和微血管张力，防止微血管血栓形成，调节白细胞粘附。在过去几十年中，关于内皮糖萼的研究数量稳步增长。糖萼是参与多种生理功能的血管的重要组成部分。糖萼损伤与多种疾病有关。糖萼的结构、生理学和病理生理学，以及糖萼降解的临床效应，将在本研究中得到阐述。我们特别致力于确定治疗方法，以使糖萼存活或修复。

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