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首页> 外文期刊>Annals of nuclear medicine >Effect of surrounding materials on iterative reconstruction-based line-source response function, and annihilations outside the source assessed by a small animal PET scanner
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Effect of surrounding materials on iterative reconstruction-based line-source response function, and annihilations outside the source assessed by a small animal PET scanner

机译：周围材料对基于迭代重建的线源响应函数以及小型动物PET扫描仪评估的源外an灭的影响

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Objective: The aims of this study were (1) to evaluate the effect of surrounding materials on the iterative reconstruction-based line-source response function (IR-RF) of 18F, 11C, 13N, and 15O using a preclinical PET system, and (2) to determine whether and how annihilation outside the source can be visualized experimentally. Methods: We performed all the measurements using the LabPET-8 PET/CT subsystem built-in the Triumph II platform (TriFoil Imaging, Inc., Northridge, CA, USA). IR-RF was measured for 18F, 11C, 13N, and 15O, and was expressed as full-width at half-maximum (FWHM) and full-width at tenth maximum (FWTM) using a glass capillary phantom mounted in materials of various densities, which were chosen to cover the wide range of real tissues. To determine whether and how annihilation outside the source can be visualized, we designed a concentric ring paper phantom, which consisted of a source at the center with 4 ring-like paper layers. Results: When the radionuclides were placed in air (material density 0 g/cm3), IR-RFs were similar among the radionuclides tested. As the surrounding material density increased, IR-RFs for higher energy-emitting radionuclides (11C, 13N, and 15O) became worse, whereas those of 18F remained relatively constant over the range of surrounding material densities (0-2.17 g/cm3). Both FWHM and FWTM values were closely correlated with mean energy of radionuclides at middle to high material densities (material density 0.94-2.17 g/cm3). The FWTM/FWHM ratio of high energy-emitting radionuclides such as 15O increased as a function of material density, which was followed by subsequent decrease at high material densities (1.2-2.17 g/cm3). Using a concentric ring paper phantom, annihilations outside the source were visible and measurable. The innermost layer was visible with all radionuclides, whereas the outer layers only with high energy positron emitters. Conclusions: The results indicate that surrounding material affects IR-RF particularly for high energy positron emitters. Furthermore, annihilation outside the radio-active source can be visualized with some circumstances such as those seen with a concentric ring paper phantom.
机译：目的：本研究的目的是（1）使用临床前PET系统评估周围材料对基于迭代重建的18F，11C，13N和15O的线源响应函数（IR-RF）的影响，以及（2）确定是否以及如何通过实验可视化源外的an灭。方法：我们使用内置于Triumph II平台（美国加利福尼亚州诺斯里奇的TriFoil Imaging，Inc.）中的LabPET-8 PET / CT子系统进行了所有测量。测量IR-RF的18F，11C，13N和15O值，并使用安装在各种密度材料中的玻璃毛细管体模将其表示为半最大全宽（FWHM）和十分之一全宽（FWTM）。 ，它们被选择为覆盖广泛的真实组织。为了确定是否可以以及如何可视化震源外的an灭，我们设计了一个同心环纸幻影，该幻影由一个位于中心的震源和4个环形纸层组成。结果：将放射性核素置于空气中（材料密度为0 g / cm3）时，所测试的放射性核素的IR-RF相似。随着周围材料密度的增加，发射更高能量的放射性核素（11C，13N和15O）的IR-RF变差，而18F的IR-RF在周围材料密度（0-2.17 g / cm3）的范围内保持相对恒定。 FWHM和FWTM值均与中等至高材料密度（材料密度0.94-2.17 g / cm3）下放射性核素的平均能量密切相关。高能发射放射性核素（例如15O）的FWTM / FWHM比随材料密度的增加而增加，随后在高材料密度（1.2-2.17 g / cm3）时降低。使用同心环纸幻影，可以看到和测量源外的an灭。所有放射性核素都可以看到最内层，而只有高能正电子发射体才可以看到外层。结论：结果表明，周围材料会影响IR-RF，特别是对于高能正电子发射器。此外，在某些情况下，例如在同心环纸幻影下看到的情况下，可以看到放射源外的an灭。

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