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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Evaluation of a two‐stage antibacterial hydrogel dressing for healing in an infected diabetic wound
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Evaluation of a two‐stage antibacterial hydrogel dressing for healing in an infected diabetic wound

机译：评价受感染糖尿病伤口愈合的两阶段抗菌水凝胶敷料

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Abstract Various types of wound dressings have been used to treat complex infections in diabetes mellitus. This study is the first to evaluate the healing effects using a two‐stage dressing in infected diabetic wounds. A two‐stage antibacterial hydrogel dressing (two‐stage dressing) was established with two time phases, an antibacterial phase and a drug release phase. We established each phase by using a swelling and rate of drug release test. These results suggested that the antimicrobial phase is activated as soon as the two‐stage dressing attaches to the skin. The drugs in the drug release layer of the dressing were released to a greater extent than expected 20–36 h after attachment to the skin, likely due to extensive water absorption. Histological analysis and measurement of vascular endothelial growth factor expression through in vivo testing suggested that the benefits of a two‐stage dressing include rapid antibacterial properties, sustained drug release, and promotion of wound healing through cell proliferation as compared with the traditional composite antibacterial hydrogel dressing. Further in vivo tests confirmed that separation of the antibacterial and drug‐releasing properties, along with biocompatibility and rapid wound closure rates made two‐stage dressings suitable for healing of infected wounds. ? 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1808–1817, 2017.
机译：摘要各种类型的伤口敷料已被用于治疗糖尿病的复杂感染。这项研究首次评估了两阶段敷料对糖尿病感染伤口的愈合效果。建立了两阶段抗菌水凝胶敷料（两阶段敷料），包括两个时间阶段、一个抗菌阶段和一个药物释放阶段。我们通过溶胀和药物释放率试验确定了每个阶段。这些结果表明，只要两段敷料贴在皮肤上，抗菌阶段就会被激活。敷料药物释放层中的药物在附着到皮肤20-36小时后释放的程度超过预期，这可能是由于广泛的吸水。组织学分析和通过体内试验测量血管内皮生长因子的表达表明，与传统的复合抗菌水凝胶敷料相比，两阶段敷料的优点包括快速抗菌性能、持续药物释放和通过细胞增殖促进伤口愈合。进一步的体内试验证实，抗菌和药物释放特性的分离，以及生物相容性和快速伤口闭合率，使得两阶段敷料适合于感染伤口的愈合？2015威利期刊有限公司，《生物医学材料研究杂志》B部分：Appl Biomater，105B:1808–1817，2017年。

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