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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Sucrose esters improve the colloidal stability of nanoethosomal suspensions of (?)‐epigallocatechin gallate for enhancing the effectiveness against UVB‐induced skin damage
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Sucrose esters improve the colloidal stability of nanoethosomal suspensions of (?)‐epigallocatechin gallate for enhancing the effectiveness against UVB‐induced skin damage

机译：蔗糖酯改善了（α） - EpigallocateChin的纳米甲骨体悬浮液的胶体稳定性，用于增强UVB诱导的皮肤损伤的有效性

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Abstract Nanoethosomal suspensions, composed of phospholipids, ethanol, and water, are novel lipid carriers. These suspensions have been reported to enhance the permeation of drugs into the skin as a result of the interdigitation effect of ethanol on the lipid bilayer of liposomes and by increasing the fluidity of lipids in the stratum corneum . The physical stability of the nanoethosomal suspension is still a critical research problem until now. This study investigated the commercial palm sucrose esters to improve the colloidal stability of nanoethosomal suspensions. The results indicated that palm sucrose esters (PSE) were effective for stabilizing nanoethosomal suspension of (?)‐epigallocatechin gallate (EGCG) from green tea. A PSE concentration of 0.15% was optimal for a nanoethosomal suspension which gave mean diameter 75.5?±?3.5 nm, zeta potential ?30.8?±?3.2 mV and polydispersity index 0.207?±?0.017. Moreover, the effectiveness of stabilization was influenced by the degree of esterification of the sucrose esters: the sucrose polyesters could prolong the stability of nanoethosomes loaded with EGCG to a year, but the sucrose monoesters only provided less than 6 months of stabilization. EGCG nanoethosomal suspension stabilized by sucrose polyesters shows better inhibition effectiveness against UVB‐induced skin damage than native EGCG. The nanoethosomal suspension has the potential for its utilization as skin care and other products. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2416–2425, 2017.
机译：摘要纳米乙醇悬浮液由磷脂、乙醇和水组成，是一种新型的脂质载体。据报道，由于乙醇在脂质体的脂质双层上的交叉作用，以及通过增加角质层中脂质的流动性，这些悬浮液可增强药物向皮肤的渗透。到目前为止，纳米乙醇悬浮液的物理稳定性仍然是一个关键的研究问题。本研究调查了商业棕榈蔗糖酯，以提高纳米乙醇悬浮液的胶体稳定性。结果表明，棕榈糖酯（PSE）能有效地稳定（？）绿茶中的表没食子儿茶素没食子酸酯（EGCG）。PSE浓度为0.15%是纳米乙醇悬浮液的最佳浓度，其平均直径为75.5？±?3.5nm，zeta电位？30.8?±?3.2 mV和多分散指数0.207？±?0.017. 此外，蔗糖酯的酯化程度也会影响稳定性的有效性：蔗糖聚酯可以将负载EGCG的纳米醇质体的稳定性延长到一年，但蔗糖单酯的稳定性不到6个月。与天然EGCG相比，蔗糖聚酯稳定的EGCG纳米乙醇悬浮液对UVB诱导的皮肤损伤具有更好的抑制效果。纳米乙醇悬浮液有潜力用作皮肤护理和其他产品？2016威利期刊有限公司，《生物医学材料研究》B部分：Appl Biomater，105B:2416–24252017。

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