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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Biological evaluation of preceramic organosilicon polymers for various healthcare and biomedical engineering applications: A review
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Biological evaluation of preceramic organosilicon polymers for various healthcare and biomedical engineering applications: A review

机译：综合医疗和生物医学工程应用的前常计有机硅聚合物的生物学评价：综述

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Preceramic organosilicon materials combining the properties of a polymer and an inorganic ceramic phase are of great interest to scientists working in biomedical sciences. The interdisciplinary nature of organosilicon polymers and their molecular structures, as well as their diversity of applications have resulted in an unprecedented range of devices and synergies cutting across unrelated fields in medicine and engineering. Organosilicon materials, especially the polysiloxanes, have a long history of industrial and medical uses in many versatile aspects as they can be easily fabricated into complex-shaped products using a wide variety of computer-aided or polymer manufacturing techniques. Thus far, intensive research activities have been mainly devoted to the processing of preceramic organosilicon polymers toward magnetic, electronic, structural, optical, and not biological applications. Herein we present innovative research studies and recent developments of preceramic organosilicon polymers at the interface with biological systems, displaying the versatility and multi-functionality of these materials. This article reviews recent research on preceramic organosilicon polymers and corresponding composites for bone tissue regeneration and medical engineering implants, focusing on three particular topics: (a) surface modifications to create tailorable and bioactive surfaces with high corrosion resistance and improved biological properties; (b) biological evaluations for specific applications, such as in glaucoma drainage devices, orthopedic implants, bone tissue regeneration, wound dressing, drug delivery systems, and antibacterial activity; and (c) in vitro and in vivo studies for cytotoxicity, genotoxicity, and cell viability. The interest in organosilicon materials stems from the fact that a vast array of these materials have complementary attributes that, when integrated appropriately with functional fillers and carefully controlled conditions, could be exploited either as polymeric Si-based composites or as organosilicon polymer-derived Si-based ceramic composites to tailor and optimize properties of the Si-based materials for various proposed applications.
机译：将聚合物和无机陶瓷相的特性结合在一起的前驱有机硅材料引起了生物医学领域科学家的极大兴趣。有机硅聚合物的跨学科性质及其分子结构，以及其应用的多样性，已经在医学和工程领域的不相关领域产生了前所未有的设备和协同效应。有机硅材料，尤其是聚硅氧烷，在工业和医疗领域有着广泛的应用历史，因为它们可以通过各种计算机辅助或聚合物制造技术轻松制造成复杂形状的产品。到目前为止，密集的研究活动主要致力于将前驱有机硅聚合物加工成磁性、电子、结构、光学而非生物应用。在此，我们介绍了在与生物系统的界面上，前驱有机硅聚合物的创新研究和最新进展，展示了这些材料的多功能性和多功能性。本文综述了用于骨组织再生和医学工程植入物的前体有机硅聚合物及其相应复合材料的最新研究，重点介绍了三个特定主题：（a）表面改性，以创造具有高耐腐蚀性和改善生物性能的可裁剪和生物活性表面；（b） 特定应用的生物学评估，如青光眼引流装置、骨科植入物、骨组织再生、伤口敷料、药物输送系统和抗菌活性；（c）细胞毒性、遗传毒性和细胞活力的体外和体内研究。人们对有机硅材料的兴趣源于这样一个事实：大量的有机硅材料具有互补的属性，当与功能填料和精心控制的条件适当结合时，可作为聚合物硅基复合材料或有机硅聚合物衍生的硅基陶瓷复合材料开发，以定制和优化硅基材料的性能，用于各种拟议应用。

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