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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Development ofNSAID-loaded nano-composite scaffolds for skin tissue engineering applications
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Development ofNSAID-loaded nano-composite scaffolds for skin tissue engineering applications

机译：用于皮肤组织工程应用的开发欧式载荷纳米复合支架

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Scar free healing together with pain management is one of the major considerations in full thickness wound healing. Extensive wounds take longer to heal without any clinical intervention and, hence, need natural or artificial extracellular matrix support for quick skin regeneration. To address these issues, medicated 3D porous biomimetic scaffolds were developed with a unique combination of biopolymers, that is, chitosan, sodium alginate, and elastin, supplemented with a non-steroidal anti-inflammatory drug (NSAID). Scaffolds were physically characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), swelling ratio analysis, and degradation studies. Findings of the performed analyses proved that these skin substitutes suitable for skin tissue engineering applications attributable to their nano-microporous structures (pore size in range of 0.085-256 mu m) allowing cell infiltration and high-water absorption capacity for management of wound exudates. Optimal dose of the loaded ibuprofen was estimated by evaluating effect of variable concentrations of ibuprofen (control, ILM-10, ILM-15, and ILM-20) on adipose tissue-derived mesenchymal stem cells (ASCs) proliferation rate. Out of all experimental groups, ILM-20 constructs were found to accelerate the proliferation rate of seeded ASCs confirming their non-cytotoxic characteristics as well potential to be used for translational scaffold-based therapies.
机译：无疤痕愈合和疼痛管理是全层伤口愈合的主要考虑因素之一。无需任何临床干预，大面积伤口需要更长时间才能愈合，因此，需要天然或人工细胞外基质支持，以实现快速皮肤再生。为了解决这些问题，利用生物聚合物的独特组合，即壳聚糖、海藻酸钠和弹性蛋白，并辅以非甾体抗炎药（NSAID），开发了药用3D多孔仿生支架。通过扫描电子显微镜（SEM）、傅立叶变换红外光谱（FTIR）、溶胀率分析和降解研究对支架进行物理表征。进行的分析结果证明，这些皮肤替代物适合皮肤组织工程应用，因为它们具有纳米微孔结构（孔径范围为0.085-256μm），允许细胞渗透，并具有处理伤口渗出物的高吸水能力。通过评估不同浓度的布洛芬（对照组、ILM-10、ILM-15和ILM-20）对脂肪组织来源的间充质干细胞（ASCs）增殖率的影响，估计了负载布洛芬的最佳剂量。在所有实验组中，发现ILM-20构建物可加速种子ASC的增殖率，证实其非细胞毒性特征以及用于转化支架疗法的潜力。

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