pH-dependent complex formation of Zn-meso-tetra(4-N-hydroxyethylpyridyl) porphyrin with cancer DNA

Karapetyan Nelli H.; Ananyan Gayane V.; Dalyan Yeva B.

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pH-dependent complex formation of Zn-meso-tetra(4-N-hydroxyethylpyridyl) porphyrin with cancer DNA

机译：Zn-Meso-Tetra（4-羟乙基吡啶基）卟啉与癌症DNA的pH依赖性复杂形成

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The complex formation between the synthetic water-soluble Zn-meso-tetra(4-N-hydroxyethylpyridyl) porphyrin (ZnTOEPyP4) and cancer DNA in comparison to healthy DNA was investigated using the UV/VIS spectrophotometry method in phosphate-buffered saline at different pHs. The increasing of DNA/porphyrin ratio leads to hypochromicity and red shift in the Soret band, which indicate the complexation of the ZnTOEPyP4 with DNA. The results show that the binding constant () and the exclusion parameter () of ZnTOEPyP4 with DNA strongly depend upon the pH. The of ZnTOEPyP4 with cancer DNA is higher than with normal DNA.

机译：采用紫外/可见分光光度法，在不同pH值的磷酸盐缓冲盐水中，研究了合成的水溶性Zn-meso四（4-N-羟乙基吡啶）卟啉（ZnTOEPyP4）与癌DNA之间形成的络合物，并与健康DNA进行了比较。DNA/卟啉比值的增加导致Soret带的低色性和红移，这表明ZnTOEPyP4与DNA的络合。结果表明，ZnTOEPyP4与DNA的结合常数（）和排斥参数（）强烈依赖于pH值。ZnTOEPyP4与癌DNA的结合常数（）高于与正常DNA的结合常数（）。

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《Journal of Biomolecular Structure and Dynamics》 |2021年第2期|共6页
作者
Karapetyan Nelli H.; Ananyan Gayane V.; Dalyan Yeva B.;
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作者单位

Yerevan State Univ Dept Mol Phys 1 Alex Manoogian St Yerevan 0025 Armenia;

Yerevan State Univ Dept Mol Phys 1 Alex Manoogian St Yerevan 0025 Armenia;

Yerevan State Univ Dept Mol Phys 1 Alex Manoogian St Yerevan 0025 Armenia;

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原文格式 PDF
正文语种 eng
中图分类分子生物学;
关键词
cancer DNA; porphyrin; spectrophotometry; binding parameters;

机译：癌症DNA;卟啉;分光光度法;结合参数;

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3. Functional Organization of Golgi N- and O-Glycosylation Pathways Involves pH-dependent Complex Formation That Is Impaired in Cancer Cells [J] . Antti Hassinen, Francois Pujol, Nina Kokkonen, The Journal of biological chemistry . 2011,第44期

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pH-dependent complex formation of Zn-meso-tetra(4-N-hydroxyethylpyridyl) porphyrin with cancer DNA

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