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首页> 外文期刊>Journal of Biophotonics >Exploring a possibility of using Raman spectroscopy for detection of Lyme disease
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Exploring a possibility of using Raman spectroscopy for detection of Lyme disease

机译：探讨使用拉曼光谱检测莱姆病的可能性

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Lyme disease (LD), one of the most prevalent tick-borne diseases in the United States (US), is caused by Borreliella burgdorferi sensu stricto (Bb). To date, in the US, LD diagnostics is primarily based on validated two-tiered serological testing, which overall exhibits low sensitivity among other drawbacks. In the present study, a potential of Raman spectroscopy (RS) to detect Bb infection in mice has been explored. For that, C3H mice were infected with wild-type Bb strains, 297, B31, or B31-derived mutant, increment vlsE. Blood samples taken prior to and post Bb infection were subjected to RS. The data demonstrated that RS did not directly detect Bb spirochetes in blood, but rather sensed biochemical changes associated with Bb infection. Despite Bb infection-associated blood changes detectable by RS were very limited, the partial least square discriminant analysis showed that the average true positive rates were 86% for 297 and 89% for B31 and increment vlsE.
机译：莱姆病（LD）是美国（US）最常见的蜱传疾病之一，由严格意义上的伯氏疏螺旋体（Bb）引起。到目前为止，在美国，LD诊断主要基于经过验证的两级血清学检测，这在其他缺点中总体上表现出低灵敏度。本研究探索了拉曼光谱（RS）检测小鼠Bb感染的潜力。因此，C3H小鼠感染了野生型Bb菌株297、B31或B31衍生突变体增量vlsE。在Bb感染之前和之后采集的血液样本均接受了RS。数据表明，RS不能直接检测血液中的Bb螺旋体，而是能感知与Bb感染相关的生化变化。尽管RS检测到的Bb感染相关血液变化非常有限，但偏最小二乘判别分析显示，297和B31及增量vlsE的平均真阳性率分别为86%和89%。

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