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首页> 外文期刊>Journal of Clinical Ultrasound: JCU >Accuracy of 2D shear wave elastography in the diagnosis of liver fibrosis in patients with chronic hepatitis C
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Accuracy of 2D shear wave elastography in the diagnosis of liver fibrosis in patients with chronic hepatitis C

机译：慢性丙型肝炎患者肝纤维化诊断中的2D剪切波弹性术的准确性

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Abstract Purpose This prospective study was conducted to assess the diagnostic accuracy of two‐dimensional shear wave elastography (2D SWE) in the diagnosis of liver fibrosis in patients with chronic liver disease and hepatitis C virus (HCV) compared with the serum liver fibrosis biomarkers using the results of liver biopsy as the reference standard. Methods We analyzed 233 consecutive HCV patients. On the same day, 2D SWE m, biochemical tests, and liver biopsy were performed. We used the METAVIR staging system and receiver operating characteristic curves for the analysis. Results The success rate of 2D‐SWE was 98.7%. The median shear wave velocities (SWVs) of patients in the F0, F1, F2, F3, and F4 stages were 1.35 m/s, 1.42 m/s, 1.58 m/s, 1.83 m/s, and 2.13 m/s, respectively, demonstrating a stepwise increase ( P ??.0001). The accuracy of 2D‐SWE in the prediction of ≥F1, ≥F2, ≥F3, and F4 was .888 (95% CI: .85‐.93), .915 (95% CI: .88‐095), .940 (95% CI: .91‐.97), and .949 (95% CI: .92‐.97), respectively. 2D‐SWE was significantly superior to serum liver fibrosis biomarkers. Conclusion 2D‐SWE was positively correlated with the severity of liver fibrosis and was more useful for to predict all liver fibrosis grades in HCV patients than liver fibrosis biomarkers.
机译：摘要目的本前瞻性研究旨在评估二维剪切波弹性成像（2D SWE）诊断慢性肝病和丙型肝炎（HCV）患者肝纤维化的准确性，并与以肝活检结果为参考标准的血清肝纤维化生物标志物进行比较。方法对233例连续性丙型肝炎患者进行分析。在同一天，进行2D SWE m、生化测试和肝活检。我们使用METAVIR分期系统和受试者操作特征曲线进行分析。结果2D-SWE的成功率为98.7%。F0期、F1期、F2期、F3期和F4期患者的平均剪切波速度（SWV）分别为1.35 m/s、1.42 m/s、1.58 m/s、1.83 m/s和2.13 m/s，呈逐步增加趋势（P？；0.0001）。2D-SWE在预测≥F1，≥F2，≥F3和F4分别为.888（95%CI:.85-93），.915（95%CI:.88-095），.940（95%CI:.91-97）和.949（95%CI:.92-97）。2D-SWE显著优于血清肝纤维化生物标志物。结论2D-SWE与肝纤维化严重程度呈正相关，与肝纤维化生物标志物相比，2D-SWE更适用于预测HCV患者的所有肝纤维化分级。

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