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首页> 外文期刊>Journal of Clinical Ultrasound: JCU >Accuracy of 2D shear wave elastography in the diagnosis of liver fibrosis in patients with chronic hepatitis C
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Accuracy of 2D shear wave elastography in the diagnosis of liver fibrosis in patients with chronic hepatitis C

机译：慢性丙型肝炎患者肝纤维化诊断中的2D剪切波弹性术的准确性

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Abstract Purpose This prospective study was conducted to assess the diagnostic accuracy of two‐dimensional shear wave elastography (2D SWE) in the diagnosis of liver fibrosis in patients with chronic liver disease and hepatitis C virus (HCV) compared with the serum liver fibrosis biomarkers using the results of liver biopsy as the reference standard. Methods We analyzed 233 consecutive HCV patients. On the same day, 2D SWE m, biochemical tests, and liver biopsy were performed. We used the METAVIR staging system and receiver operating characteristic curves for the analysis. Results The success rate of 2D‐SWE was 98.7%. The median shear wave velocities (SWVs) of patients in the F0, F1, F2, F3, and F4 stages were 1.35 m/s, 1.42 m/s, 1.58 m/s, 1.83 m/s, and 2.13 m/s, respectively, demonstrating a stepwise increase ( P ??.0001). The accuracy of 2D‐SWE in the prediction of ≥F1, ≥F2, ≥F3, and F4 was .888 (95% CI: .85‐.93), .915 (95% CI: .88‐095), .940 (95% CI: .91‐.97), and .949 (95% CI: .92‐.97), respectively. 2D‐SWE was significantly superior to serum liver fibrosis biomarkers. Conclusion 2D‐SWE was positively correlated with the severity of liver fibrosis and was more useful for to predict all liver fibrosis grades in HCV patients than liver fibrosis biomarkers.
机译：摘要目的，该前瞻性研究评估了与血清肝纤维化生物标志物相比，评估二维剪力波弹性摄影（2D SWE）在慢性肝病和丙型肝炎病毒（HCV）患者肝纤维化诊断中的诊断准确性肝活检结果作为参考标准。方法分析了连续233例HCV患者。在同一天，进行2D SWE M，生化试验和肝脏活组织检查。我们使用了Metavir分期系统和接收器操作特性曲线进行分析。结果2D-SWE的成功率为98.7％。 F0，F1，F2，F3和F4级中患者的中值剪切波速度（SWV）为1.35 m / s，1.42 m / s，1.58 m / s，1.83 m / s和2.13 m / s，分别证明逐步增加（P？＆ 0001）。在预测≥F1，≥F2，≥F3和F4的预测中的2D-SWE的精度为.888（95％CI：.85-.93），.915（95％CI：.88-095）。 940（95％CI：.91-.97），分别为.949（95％CI：.92-.97）。 2D-SWE显着优于血清肝纤维化生物标志物。结论2D-SWE与肝纤维化的严重程度正相关，对HCV患者的所有肝纤维化等级呈正相关，而不是肝纤维化生物标志物。

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