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首页> 外文期刊>Behavioural pharmacology >Chronic administration of clozapine alleviates reversal-learning impairment in isolation-reared rats.
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Chronic administration of clozapine alleviates reversal-learning impairment in isolation-reared rats.

机译：长期服用氯氮平可减轻孤立饲养大鼠的逆向学习障碍。

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Isolation rearing has been used for inducing schizophrenia-like symptoms in rats. Human schizophrenics have deficits in prefrontal-dysfunction-related cognitive/behavioral flexibility. Rats with lesions of the medial prefrontal cortex perform poorly in reversal learning. It is uncertain whether isolation rearing, however, causes reversal-learning impairment in adult rats. Using the rotating T maze, this study examined the effect of chronic administration of clozapine on visual discrimination learning and reversal learning in isolation-reared and socially reared adult rats. The results show that isolation-reared rats without clozapine injection performed significantly worse than socially reared rats in reversal learning but not in acquisition learning. Chronic injection of clozapine (5 or 10 mg/kg) in isolation-reared rats significantly improved reversal learning but had no effects on acquisition learning. Further data analyses show that in both the inhibition phase and the new-strategy-acquisition phase of reversal learning, isolation-reared rats needed significantly more correct-response trials to reach the criterion than socially reared rats, and clozapine significantly reduced the isolation-induced impairment of reversal learning only in the new-strategy-acquisition phase. In socially reared rats, clozapine had a dose-related interfering effect on reversal learning but not acquisition learning. This study supports the use of isolation rearing as a model for investigating the neurodevelopmental hypothesis of schizophrenia.
机译：隔离饲养已用于在大鼠中诱发精神分裂症样症状。人类精神分裂症患者的前额叶功能障碍相关的认知/行为灵活性不足。患有内侧前额叶皮层损伤的大鼠在逆向学习中表现较差。然而，尚不清楚孤立饲养是否会引起成年大鼠的逆向学习障碍。本研究使用旋转的T迷宫，研究了长期服用氯氮平对孤立饲养和社交饲养的成年大鼠的视觉歧视学习和逆向学习的影响。结果表明，未服用氯氮平的隔离饲养的大鼠在逆向学习中的表现显着低于社交饲养的大鼠，但在习得性学习中则没有。在隔离饲养的大鼠中长期注射氯氮平（5或10 mg / kg）可显着改善逆向学习，但对习得性学习没有影响。进一步的数据分析表明，在逆向学习的抑制阶段和新策略获取阶段中，与社交饲养的大鼠相比，隔离饲养的大鼠需要更多的正确反应试验才能达到标准，氯氮平显着降低了隔离诱导的大鼠逆向学习的障碍仅在新策略获取阶段才出现。在社交饲养的大鼠中，氯氮平对逆向学习具有剂量相关的干扰作用，但对习得性学习没有影响。这项研究支持使用隔离饲养作为研究精神分裂症神经发育假说的模型。

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