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首页> 外文期刊>Andrologia >Mitigation of paracetamol-induced reproductive damage by chrysin in male rats via reducing oxidative stress
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Mitigation of paracetamol-induced reproductive damage by chrysin in male rats via reducing oxidative stress

机译：菊花蛋白通过减少氧化应激减轻对乙酰氨基酚诱导的雄性大鼠生殖生殖损伤

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摘要

Paracetamol (PRC) is a nonsteroidal anti-inflammatory drug used widely as a painkiller for various diseases and as the symptomatic flu cure in several countries worldwide. PRC toxicity may occur under conditions of the overdose usage. Chrysin (CR) is a flavonoid that is naturally present in several plants, honey and propolis. The aim of this study was to investigate the effects of CR (at the doses of 25 mg kg(-1) and 50 mg kg(-1)) pre-treatment over seven consecutive days against PRC-induced reproductive toxicity in male rats. Our results showed that PRC toxicity decreased the sperm motility, and increased dead sperm rate, abnormal sperm cell rate, apoptosis and MDA levels in testicular tissues. Pre-treatment with CR at the dose of 25 and 50 mg kg(-1) for 7 days mitigated side effects of acute PRC toxicity in male reproductive system proportionally in a dose-dependent manner. This possible protection mechanism might be dependent on the antioxidant activity of CR. In conclusion, pre-treatment with CR at the dose of 25 and 50 mg kg(-1) for 7 days can be the beneficial against PRC-induced reproductive toxicity proportionally in a dose-dependent manner.
机译：扑热息痛（PRC）是一种非甾体抗炎药，在全球多个国家广泛用作各种疾病的止痛药和症状性流感的治疗方法。在过量使用的条件下，可能发生PRC毒性。菊花（CR）是一种类黄酮，天然存在于多种植物，蜂蜜和蜂胶中。这项研究的目的是调查连续七天的CR（在25 mg kg（-1）和50 mg kg（-1）剂量下）对PRC诱导的雄性大鼠生殖毒性的影响。我们的结果表明，PRC毒性降低了精子活力，并增加了睾丸组织中的精子死率，精子异常率，凋亡和MDA水平。用25和50 mg kg（-1）的CR进行7天的预处理，以剂量依赖的方式成比例地缓解了雄性生殖系统中急性PRC毒性的副作用。这种可能的保护机制可能取决于CR的抗氧化活性。总之，以25和50 mg kg（-1）的剂量进行7天的CR预处理可以按剂量依赖的方式成比例地对抗PRC诱导的生殖毒性。

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