Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery

Fan Mingliang; Liang Xiaofei; Yang Danbo; Pan Xiaorong; Li Zonghai; Wang Hongyang; Shi Bizhi

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Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery

机译：表皮生长因子受体靶向肽缀合的磷脂纤维素用于多柔比星输送

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Specific targeting of tumor cells to achieve higher drug levels in tumor tissue and to overcome side effects is the major goal in cancer chemotherapy. In this study, we used a tumor targeting peptide, GE11, to conjugate onto the surface of doxorubicin encapsulated phospholipid micelles. The GE11 peptide triggered specific binding to epidermal growth factor receptor (EGFR), leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation in the tumors in vivo. The results indicated that GE11 conjugated phospholipid micelles should have potential applications in cancer therapy.

机译：肿瘤细胞的特异性靶向性以达到肿瘤组织中更高的药物水平并克服副作用是癌症化疗的主要目标。在这项研究中，我们使用肿瘤靶向肽GE11结合到阿霉素包裹的磷脂胶束表面。GE11肽触发了与表皮生长因子受体（EGFR）的特异性结合，从而在体外增强细胞摄取和细胞毒性，并在体内肿瘤中高度积累。结果表明，GE11结合磷脂胶束在肿瘤治疗中具有潜在的应用前景。

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来源
《Journal of drug targeting》 |2016年第10期|共9页
作者
Fan Mingliang; Liang Xiaofei; Yang Danbo; Pan Xiaorong; Li Zonghai; Wang Hongyang; Shi Bizhi;
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作者单位

Shanghai Jiao Tong Univ Sch Med Renji Hosp Shanghai Canc Inst State Key Lab Oncogenes &

Rela;

Shanghai Jiao Tong Univ Sch Med Renji Hosp Shanghai Canc Inst State Key Lab Oncogenes &

Rela;

Shanghai Jiao Tong Univ Sch Med Renji Hosp Shanghai Canc Inst State Key Lab Oncogenes &

Rela;

Shanghai Jiao Tong Univ Sch Med Renji Hosp Shanghai Canc Inst State Key Lab Oncogenes &

Rela;

Shanghai Jiao Tong Univ Sch Med Renji Hosp Shanghai Canc Inst State Key Lab Oncogenes &

Rela;

Shanghai Jiao Tong Univ Sch Med Renji Hosp Shanghai Canc Inst State Key Lab Oncogenes &

Rela;

Shanghai Jiao Tong Univ Sch Med Renji Hosp Shanghai Canc Inst State Key Lab Oncogenes &

Rela;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Doxorubicin; epidermal growth factor receptor; GE11; micelles; targeted drug delivery;

机译：多柔比星;表皮生长因子受体;GE11;胶束;靶向药物递送;

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1. Epidermal growth factor receptor-targeted ultra-small superparamagnetic iron oxide particles for magnetic resonance molecular imaging of lung cancer cells in vitro [J] . CHEN Chun-li, HU Guang-yuan, MEI Qi, 中华医学杂志（英文版） . 2012,第013期
2. Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery [J] . Fan Mingliang, Liang Xiaofei, Yang Danbo, Journal of drug targeting . 2016,第1a10期

机译：表皮生长因子受体靶向肽缀合的磷脂纤维素用于多柔比星输送
3. Design and biological activity of epidermal growth factor receptor-targeted peptide doxorubicin conjugate [J] . Fan Mingliang, Yang Danbo, Liang Xiaofei, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2015,第Null期

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4. Targeting Epidermal Growth Factor Receptors in Recurrent Glioblastoma Via a Novel Epithelial Growth Factor Receptor-Conjugated Nanocell Doxorubicin Delivery System [J] . Kwan Kevin, Schneider Julia R., Kobets Andrew, Neurosurgery . 2018,第3期

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5. Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-Targeted Gelatin Nanoparticles [C] . Jing Xu, Mansoor Amiji NSTI nanotechnology conference and expo;Nanotech conference expo;NSTI-Nanotech 2011;TechConnect world annual conference expo . 2011

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6. Spectroscopic studies of the epidermal growth factor and epidermal growth factor receptor system: Native fluorescence and spin-labeling approaches. [D] . Yarema, Kristin Anne. 2000

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9. Altered Regulation of Intercellular Communication by Epidermal Growth Factor, Transforming Growth Factor-Beta and Peptide Hormones in Normal Human Keratinocytes [R] . Trosko, J. E., Madhukar, B. V., Oh, S. Y., 1989

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Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery

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