Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery

Fan Mingliang; Liang Xiaofei; Yang Danbo; Pan Xiaorong; Li Zonghai; Wang Hongyang; Shi Bizhi

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Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery

机译：表皮生长因子受体靶向肽缀合的磷脂纤维素用于多柔比星输送

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Specific targeting of tumor cells to achieve higher drug levels in tumor tissue and to overcome side effects is the major goal in cancer chemotherapy. In this study, we used a tumor targeting peptide, GE11, to conjugate onto the surface of doxorubicin encapsulated phospholipid micelles. The GE11 peptide triggered specific binding to epidermal growth factor receptor (EGFR), leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation in the tumors in vivo. The results indicated that GE11 conjugated phospholipid micelles should have potential applications in cancer therapy.

机译：肿瘤细胞的特异性靶向在肿瘤组织中获得更高的药物水平，克服副作用是癌症化疗的主要目标。在这项研究中，我们使用肿瘤靶向肽Ge11，将缀合到多柔比蛋白包封的磷脂胶束表面上。 GE11肽引发与表皮生长因子受体（EGFR）的特异性结合，导致体内肿瘤中的体外增强和细胞毒性增强和高度积累。结果表明，GE11缀合的磷脂胶束应具有癌症治疗的潜在应用。

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来源
《Journal of drug targeting》 |2016年第10期|共9页
作者
Fan Mingliang; Liang Xiaofei; Yang Danbo; Pan Xiaorong; Li Zonghai; Wang Hongyang; Shi Bizhi;
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作者单位

Shanghai Jiao Tong Univ Sch Med Renji Hosp Shanghai Canc Inst State Key Lab Oncogenes &

Rela;

Shanghai Jiao Tong Univ Sch Med Renji Hosp Shanghai Canc Inst State Key Lab Oncogenes &

Rela;

Shanghai Jiao Tong Univ Sch Med Renji Hosp Shanghai Canc Inst State Key Lab Oncogenes &

Rela;

Shanghai Jiao Tong Univ Sch Med Renji Hosp Shanghai Canc Inst State Key Lab Oncogenes &

Rela;

Shanghai Jiao Tong Univ Sch Med Renji Hosp Shanghai Canc Inst State Key Lab Oncogenes &

Rela;

Shanghai Jiao Tong Univ Sch Med Renji Hosp Shanghai Canc Inst State Key Lab Oncogenes &

Rela;

Shanghai Jiao Tong Univ Sch Med Renji Hosp Shanghai Canc Inst State Key Lab Oncogenes &

Rela;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Doxorubicin; epidermal growth factor receptor; GE11; micelles; targeted drug delivery;

机译：多柔比星;表皮生长因子受体;GE11;胶束;靶向药物递送;

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1. Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery [J] . Fan Mingliang, Liang Xiaofei, Yang Danbo, Journal of drug targeting . 2016,第1a10期

机译：表皮生长因子受体靶向肽缀合的磷脂纤维素用于多柔比星输送
2. Targeting Epidermal Growth Factor Receptors in Recurrent Glioblastoma Via a Novel Epithelial Growth Factor Receptor-Conjugated Nanocell Doxorubicin Delivery System [J] . Kwan Kevin, Schneider Julia R., Kobets Andrew, Neurosurgery . 2018,第3期

机译：通过新型上皮生长因子受体缀合的纳米细胞多柔比星输送系统靶向复发性胶质母细胞瘤中的表皮生长因子受体
3. Facile Synthesis of Cyclic Peptide–Phthalocyanine Conjugates for Epidermal Growth Factor Receptor-Targeted Photodynamic Therapy [J] . Jacky C. H. Chu, Wing-Ping Fong, Clarence T. T. Wong, Journal of Medicinal Chemistry . 2021,第4期

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4. Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-Targeted Gelatin Nanoparticles [C] . Jing Xu, Mansoor Amiji NSTI nanotechnology conference and expo;Nanotech conference expo;NSTI-Nanotech 2011;TechConnect world annual conference expo . 2011

机译：使用表皮生长因子受体靶向明胶纳米粒子在人类胰腺癌细胞中的基因传递和转染。
5. Spectroscopic studies of the epidermal growth factor and epidermal growth factor receptor system: Native fluorescence and spin-labeling approaches. [D] . Yarema, Kristin Anne. 2000

机译：表皮生长因子和表皮生长因子受体系统的光谱研究：天然荧光和自旋标记方法。
6. Novel PAMAM-PEG-Peptide Conjugates for siRNA Delivery Targeted to the Transferrin and Epidermal Growth Factor Receptors [O] . Koldo Urbiola, Laura Blanco-Fernández, Manfred Ogris, 2018

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7. Synthesis and biological evaluation of an epidermal growth factor receptor-targeted peptide-conjugated phthalocyanine-based photosensitiser [O] . Evelyn Y. Xue, Roy C. H. Wong, Clarence T. T. Wong, 2019

机译：表皮生长因子受体靶向肽 - 共轭酞菁光敏蛋白的合成与生物学评价
8. Altered Regulation of Intercellular Communication by Epidermal Growth Factor, Transforming Growth Factor-Beta and Peptide Hormones in Normal Human Keratinocytes [R] . Trosko, J. E., Madhukar, B. V., Oh, S. Y., 1989

机译：改变正常人角质形成细胞表皮生长因子，转化生长因子-β和肽激素对细胞间通讯的调节作用

Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery

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