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首页> 外文期刊>Journal of drug targeting >Collagen nanofiber containing silver nanoparticles for improved wound-healing applications
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Collagen nanofiber containing silver nanoparticles for improved wound-healing applications

机译：含银纳米粒子的胶原纳米粒子用于改善伤口愈合应用

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Electrospun nanofibers showing great promise for fabricating nanostructured materials might help to improve the quality of wound care. The present study aimed to investigate the wound-healing potential of collagen nanofiber mats containing silver nanoparticles. Silver nanoparticles (AgNPs) synthesized by the chemical reduction method were incorporated in collagen nanofibers during the electrospinning process. Characterization of electrospun nanofiber mats revealed a mean fiber diameters in the range of 300-700 nm with a sustained release of silver ions shown to follow pseudo-order kinetics. MIC of AgNPs against Staphylococcus aureus and Pseudomonas aeruginosa were evaluated using micro-dilution assay and further antimicrobial activity of fabricated nanofibers was performed. Finally, in vivo studies were performed to demonstrate the wound-healing efficacy of composite nanofibers. In vitro results confirmed the potential antimicrobial efficacy provided by AgNPs and AgNPs composite nanofibers, essential to provide an aseptic environment at the wound site. In vivo study revealed that the rate of wound healing of the composite nanofiber mats was found to be accelerated compared with plain collagen nanofibers. Histology analysis revealed an accelerated re-epithelization, collagen production, and better wound contraction with AgNPs composite collagen nanofibers.
机译：电纺纳米纤维在制备纳米结构材料方面表现出巨大的潜力，可能有助于提高伤口护理的质量。本研究旨在研究含银纳米颗粒的胶原纳米纤维垫的伤口愈合潜力。通过化学还原法合成的银纳米颗粒（AgNPs）在静电纺丝过程中被并入胶原纳米纤维中。电纺纳米纤维垫的表征显示，平均纤维直径在300-700 nm范围内，银离子的持续释放遵循伪序动力学。使用微量稀释法评估AgNPs对金黄色葡萄球菌和铜绿假单胞菌的MIC，并对制备的纳米纤维进行进一步的抗菌活性测试。最后，进行了体内研究，以证明复合纳米纤维的伤口愈合效果。体外实验结果证实了AgNPs和AgNPs复合纳米纤维的潜在抗菌效果，这对于在伤口部位提供无菌环境至关重要。体内研究表明，与普通胶原纳米纤维相比，复合纳米纤维垫的伤口愈合速度加快。组织学分析显示，AgNPs复合胶原纳米纤维可加速再上皮化、胶原生成和更好的伤口收缩。

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