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首页> 外文期刊>Journal of cosmetic dermatology >A hyaluronic acid-based filler reduces lipolysis in human mature adipocytes and maintains adherence and lipid accumulation of long-term differentiated human preadipocytes
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A hyaluronic acid-based filler reduces lipolysis in human mature adipocytes and maintains adherence and lipid accumulation of long-term differentiated human preadipocytes

机译：透明质酸的填料减少了人成熟脂肪细胞的脂解，保持了长期分化的人类前脂肪细胞的粘附和脂质积累

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摘要

The beneficial role of subcutaneous adipose tissue in skin rejuvenation derived from its capacity to fill the under-layer volumes but also from its ability to regulate the extracellular matrix production by dermis fibroblasts. Hyaluronic acid (HA), a major component of the extracellular matrix, is a commonly used injectable dermal filler showing excellent efficiencies to maintain tissue augmentation even after its biodegradation. To improve their stability, the HA molecules can also be "cross-linked" to each other. The effects of cross-linked HA-based fillers on the dermal structure are well known. For safety reasons, most of the physicians prefer to use the blunt cannula for injections. However, evidences showed that the cannula could not be located in the dermis, but it passes through immediate hypodermis and the long-lasting effect of cross-linked HA-based fillers may be related to its effects on adipose tissue. To test whether cross-linked HA has a direct effect on human adipocytes, we treated isolated adipocytes and precursors cells from human skin donors with cross-linked HA. Biochemical and cellular analysis demonstrated that treatment by cross-linked HA showed beneficial effects on differentiated cell adherence and survival as well as reduced basal and induced lipolysis in fully mature adipocytes. Taken together, these data showed that cross-linked HA promoted cell adherence and preserved the adipogenic capacity of preadipocytes during prolonged cell culture, bringing additional evidences of the beneficial role of cross-linked HA-based fillers in maintenance of the subcutaneous fat mass. This first study could defend a preventive approach to facial volume loss during natural aging.
机译：皮下脂肪组织在皮肤再生中的有益作用源于其填充下层体积的能力，也源于其调节真皮成纤维细胞产生细胞外基质的能力。透明质酸（HA）是细胞外基质的主要成分，是一种常用的可注射真皮填充剂，即使在其生物降解后，仍能有效维持组织增生。为了提高稳定性，HA分子也可以相互“交联”。交联HA基填料对真皮结构的影响是众所周知的。出于安全原因，大多数医生更喜欢使用钝套管进行注射。然而，有证据表明，套管不能位于真皮内，但它会立即穿过皮下组织，交联HA基填料的长期作用可能与其对脂肪组织的作用有关。为了测试交联HA是否对人类脂肪细胞有直接影响，我们用交联HA处理从人类皮肤供体分离的脂肪细胞和前体细胞。生化和细胞分析表明，交联HA治疗对分化细胞的粘附和存活以及减少完全成熟脂肪细胞的基础和诱导脂肪分解具有有益作用。综上所述，这些数据表明，交联HA促进了细胞粘附，并在长期细胞培养期间保留了前脂肪细胞的成脂能力，进一步证明了交联HA基填料在维持皮下脂肪团方面的有益作用。这第一项研究可以为自然衰老期间面部体积减少的预防方法辩护。

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