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Spasticity and spastic dystonia: the two faces of velocity-dependent hypertonia

机译:痉挛和痉挛性肌剧:速度依赖性过度血管的两个面

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摘要

Background: Spasticity and spastic dystonia are two separate phenomena of the upper motor neuron syndrome. Spasticity is clinically defined by velocity-dependent hypertonia and tendon jerk hyperreflexia due to the hyper-excitability of the stretch reflex. Spastic dystonia is the inability to relax a muscle leading to a spontaneous tonic contraction. Both spasticity and spastic dystonia are present in patients who are at rest; however, only patients with spasticity are actually able to kept their muscles relaxed prior to muscle stretch. The idea that has inspired the present work is that also in patients with spastic dystonia the stretch reflex is likely to be hyper-excitable. Therefore, velocity-dependent hypertonia could be mediated not only by spasticity, but also by spastic dystonia.
机译:背景:痉挛和痉挛性肌张力障碍是上运动神经元综合征的两种不同现象。痉挛在临床上被定义为速度依赖性张力亢进和肌腱痉挛性反射亢进,这是由于拉伸反射的高兴奋性。痉挛性肌张力障碍是指无法放松肌肉,导致自发的强直性收缩。处于休息状态的患者同时存在痉挛和痉挛性肌张力障碍;然而,只有痉挛患者才能在肌肉拉伸之前保持肌肉放松。启发目前工作的想法是,痉挛性肌张力障碍患者的拉伸反射也可能是高兴奋性的。因此,速度依赖性高张力不仅可以通过痉挛来调节,还可以通过痉挛性肌张力障碍来调节。

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