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首页> 外文期刊>Digestive diseases >Endoscopic and Pathological Characteristics of Helicobacter pylori Infection-Negative Early Gastric Cancer
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Endoscopic and Pathological Characteristics of Helicobacter pylori Infection-Negative Early Gastric Cancer

机译：幽门螺杆菌感染阴性早期胃癌的内镜和病理特征

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Background: The characteristics of Helicobacter pylori (HP) infection-negative gastric cancer (HPINGC) have not been well documented because of the rareness. The aim of this study was to classify HPINGC endoscopically and clinicopathologically. Methods: This retrospective study included 1,741 early gastric cancer lesions and evaluated their HP infection status. Expression levels of MUC5AC, MUC6, MUC2, CD10, p53, MIB-1, pepsinogen-I, H~(+)/K~(+) ATPase, chromogranin A, E-cadherin, and gastrin were evaluated in tumors by immunohistochemistry (IHC). Results: Among the analyzed lesions, 19 (1.1%) were diagnosed as HPINGC and classified into 6 types: undifferentiated (5 lesions), fundic gland (2 lesions), cardiac gland (1 lesion), pyloric gland (3 lesions), foveolar (5 lesions), and mixed (3 lesions) types. Undifferentiated lesions were of pale color, with unclear demarcation and decreased E-cadherin expression. Fundic-type lesions were tan to reddish in color, with submucosal tumor-like protrusions, and positive for pepsinogen-I and H~(+)/K~(+) ATPase. The cardiac gland type was located in the gastroesophageal junction and was positive for MUC6 and pepsinogen-I. Pyloric gland-type lesions were of the same color as normal mucosa, with mild elevation and unclear demarcation, likely positive for CD10 and chromogranin A. Foveolar epithelial-type lesions were white and elevated, with defined demarcation, and contained MUC5AC-positive cells. Mixed-type lesions, showing various staining patterns in IHC, had both elevated and depressed shape and reddish color. Conclusion: Endoscopic observation and IHC were useful for classifying the characteristics of HPINGC, which may preserve the characteristics of its region of origin.
机译：背景：由于幽门螺杆菌（HP）感染阴性胃癌（HPINGC）的罕见性，其特征尚未得到很好的记录。本研究的目的是从内镜和临床病理角度对HPINGC进行分类。方法：对1741例早期胃癌患者进行回顾性研究，评估其HP感染状况。通过免疫组织化学（IHC）评估肿瘤中MUC5AC、MUC6、MUC2、CD10、p53、MIB-1、胃蛋白酶原-I、H~（++）/K~（++）ATP酶、嗜铬粒蛋白A、E-钙粘蛋白和胃泌素的表达水平。结果：在分析的病变中，19个（1.1%）被诊断为HPINGC，分为6种类型：未分化型（5个病变）、胃底腺型（2个病变）、心脏腺型（1个病变）、幽门腺型（3个病变）、小凹型（5个病变）和混合型（3个病变）。未分化病灶颜色苍白，界限不清，E-钙粘蛋白表达降低。眼底型病变呈棕褐色至微红色，粘膜下有肿瘤样突起，胃蛋白酶原-I和H~（++）/K~（++）ATP酶阳性。心脏腺体类型位于胃食管交界处，MUC6和胃蛋白酶原-I呈阳性。幽门腺体类型的病变与正常粘膜颜色相同，轻度隆起，界限不清，CD10和嗜铬粒蛋白A可能呈阳性。小凹上皮型病变呈白色，隆起，界限明确，含有MUC5AC阳性细胞。混合型病变在IHC中表现出不同的染色模式，既有隆起的，也有凹陷的形状和红色。结论：内镜观察和IHC有助于对HPINGC的特征进行分类，从而保留其起源区域的特征。

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