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首页> 外文期刊>Andrologia >Accumulation of mercury and its effects on testicular functions in rats intoxicated orally by methylmercury
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Accumulation of mercury and its effects on testicular functions in rats intoxicated orally by methylmercury

机译：甲基汞中毒口服后大鼠体内汞的积累及其对睾丸功能的影响

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摘要

All forms of mercury are considered poisonous. Methylmercury, one organic form, is highly toxic to many organs. The aim of the present study was to assess the effects of this form on the reproductive system in the rat. For this, 20 male rats were divided into two groups. One, which is considered as reference, received tap water. The second group received tap water containing methylmercury at the rate of 20 mg l-1 for 8 weeks. At the end of the experiment, blood samples were collected for the determination of total mercury and plasma testosterone. The left testes were used for the determination of total mercury and histological examination. Appropriate centrifugation was applied on right testes to extract interstitial and seminiferous tubular fluids. The epididymides were homogenised for the sperm count. Our results showed a dramatic fall in the plasma testosterone in the contaminated animals. The fall in plasmatic testosterone seems to be in relation with the decrease in the secretion of testosterone. In association with this, the concentration of testosterone in seminiferous tubules fluid dropped about 55% in the poisoned animals in comparison with the controls. Despite this, no decrease in the epididymal sperm count in contaminated rats was observed.
机译：所有形式的汞都被认为是有毒的。甲基汞是一种有机形式，对许多器官有剧毒。本研究的目的是评估这种形式对大鼠生殖系统的影响。为此，将20只雄性大鼠分为两组。其中一个被认为是参考用水。第二组接受含甲基汞的自来水，剂量为20 mg l-1，持续8周。实验结束时，收集血液样本以确定总汞和血浆睾丸激素。左睾丸用于测定总汞和组织学检查。在右睾丸上进行适当的离心，以提取间质和生精的管状液体。将附睾均质化以用于精子计数。我们的结果表明，受污染动物的血浆睾丸激素急剧下降。血浆睾丸激素的下降似乎与睾丸激素分泌减少有关。与此相关，与对照组相比，中毒动物的生精小管液中睾丸激素的浓度下降了约55％。尽管如此，在受污染的大鼠中未观察到附睾精子数量减少。

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