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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Association of Guillain-Barre syndrome with COVID-19 infection: An updated systematic review
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Association of Guillain-Barre syndrome with COVID-19 infection: An updated systematic review

机译：与Covid-19感染的Guillain-Barre综合征结合：更新的系统评论

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Objective: The systematic review aimed to determine demographic characteristics, clinical features, lab evaluation, management and complications of the studies focusing on Guillain-Barre syndrome (GBS) as a sequele of novel coronavirus (COVID-19) infection. Methods: After protocol registration, PubMed, Web of Science and Cumulative Index to Nursing & Allied Health Literature (CINHAL) databases were searched for relevant articles using MeSH key-words and imported into referencing/review softwares. The data, regarding demographic and clinical characteristics, diagnostic workup and management, was analyzed in International Business Machines (IBM) Statistics SPSS 21. Many statistical tests, such as t-test and the Mann?Whitney U test, were used. P < 0.05 was considered significant. Results: We identified 64 relevant articles. The mean age of the patients was 56 ? 16 years; the majority were males (64.9%). Among the neurological findings, paresthesia was the most typical symptom (48.9%). Most of the patients had been diagnosed by reverse transcriptase-polymerase chain reaction (RT-PCR) (69.2%). Two-third of the patients received immunoglobulins (IVIg) (77.7%). Although functions recovered in most patients, there were four patients with facial diplegia during follow-up (4.26%). Acute inflammatory demyelinating polyneuropathy (AIDP) was more likely to be associated with paresis of the lower extremity (p < 0.05) and higher levels of glucose on cerebrospinal fluid (CSF) analysis (p < 0.05). These patients were more likely to receive IVIg (p < 0.05) and develop respiratory insufficiency, subsequently (p < 0.05). Conclusions: GBS is being recognized as one of the many presentations of the COVID-19 infection. Although the common form is AIDP that might lead to complications, other variants are possible as well, and more studies are needed to focus on those subvariants.
机译：目的：新型冠状病毒2019冠状病毒疾病（Guiab-BARRE综合征）的流行病学特征、临床特征、实验室评估、治疗及并发症的系统评价。方法：在方案注册后，使用MeSH关键词搜索PubMed、Web of Science和护理与相关健康文献累积索引（CINHAL）数据库中的相关文章，并导入参考/综述软件。有关人口统计学和临床特征、诊断检查和管理的数据在国际商业机器（IBM）统计软件SPSS 21中进行了分析。许多统计检验，比如t检验和Mann检验？采用惠特尼U检验。P<0.05被认为是显著的。结果：我们确定了64篇相关文章。患者的平均年龄是56岁？16年；大多数为男性（64.9%）。在神经系统表现中，感觉异常是最典型的症状（48.9%）。大多数患者通过逆转录聚合酶链反应（RT-PCR）确诊（69.2%）。三分之二的患者接受了免疫球蛋白（IVIg）（77.7%）。虽然大多数患者功能恢复，但随访期间有4例患者面部双瘫（4.26%）。急性炎性脱髓鞘性多发性神经病（AIDP）更可能与下肢轻瘫（p<0.05）和脑脊液（CSF）分析中较高的葡萄糖水平有关（p<0.05）。这些患者更有可能接受IVIg（p<0.05），随后出现呼吸功能不全（p<0.05）。结论：GBS 2019冠状病毒疾病的多个表现之一。虽然AIDP的常见形式可能导致并发症，但也可能存在其他变体，需要更多的研究来关注这些亚变体。

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