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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Chitosan microencapsulation of the dispersed phase of an O/W nanoemulsion to hydrochlorothiazide delivery
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Chitosan microencapsulation of the dispersed phase of an O/W nanoemulsion to hydrochlorothiazide delivery

机译：壳聚糖微胶囊分散相的O / W纳米乳剂至氢氯噻嗪递送

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摘要

In view of biopharmaceutical limitations of hydrochlorothiazide (HCTZ), Trojan-type mucoadhesive systems were proposed, aiming to improve HCTZ pharmacological properties by modulating its release. Nanoemulsions were formed spontaneously by combining medium-chain triglycerides (Lipoid (R) S75 and Pluronic (R) F68) and high encapsulation efficiency was obtained. The mucoadhesive properties were provided by chitosan and microencapsulation of nanoemulsions in spray-dryer was successfully achieved by using Aerosil (R) as wall material. The rapid redispersion of nanoemulsion in simulated fluids led to a fast and complete release of HCTZ in gastric medium. The pharmacodynamics of HCTZ was improved, extending the diuretic activity. Once a simple and low-energy method contributed to obtain stable mucoadhesive nanoemulsions, advantages in terms of production could also be achieved, allowing easy scaling up. This novel mucoadhesive Trojan particulate system of HCTZ showed to be a promising approach to overcome limitations in terms of absorption and consequently improve the therapeutic efficacy.
机译：鉴于氢氯噻嗪（HCTZ）的生物药剂学局限性，提出了特洛伊型粘液粘附系统，旨在通过调节HCTZ的释放来改善其药理学特性。通过结合中链甘油三酯（类脂（R）S75和Pluronic（R）F68）自发形成纳米乳液，获得了较高的封装效率。以壳聚糖为黏合剂，以Aerosil（R）为壁材，在喷雾干燥器中成功地实现了纳米乳液的微胶囊化。纳米乳剂在模拟液体中的快速再分散导致HCTZ在胃介质中快速完全释放。HCTZ的药效学得到改善，延长了利尿活性。一旦一种简单且低能的方法有助于获得稳定的粘液粘合剂纳米乳液，就可以实现生产方面的优势，从而易于扩大规模。这种新型的HCTZ粘液粘附颗粒系统被证明是一种很有前途的方法，可以克服吸收方面的限制，从而提高治疗效果。

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