首页> 美国政府科技报告 >Sequential Delivery of BMP-2 and IGF-1 Using a Chitosan Gel with gelatin Microspheres Enhances Early osteoblastic Differentiation.
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Sequential Delivery of BMP-2 and IGF-1 Using a Chitosan Gel with gelatin Microspheres Enhances Early osteoblastic Differentiation.

机译:使用具有明胶微球的壳聚糖凝胶顺序递送Bmp-2和IGF-1增强早期成骨细胞分化。

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The purpose of this study was to develop and characterize a chitosan gel/gelatin microsphere (MSs) dual delivery system for sequential release of bone morphogenetic protein 2 (BMP 2) and insulin like growth factor 1 (IGF 1) to enhance osteoblast differentiation in vitro. We made and characterized the delivery system based on its degree of cross linking, degradation, and release kinetics. We also evaluated the cyto-toxicity of the delivery system and the effect of growth factors on cell response using pre osteoblast W 20 17 bone marrow stromal cells. IGF 1 was first loaded into Mss, and then the IGF 1 containing MSs were encapsulated into the chitosan gel which contained BMP 2.

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