...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Annals of Tropical Paediatrics >Evaluation of glomerular and tubular renal function in neonates with birth asphyxia.
【24h】

Evaluation of glomerular and tubular renal function in neonates with birth asphyxia.

机译：新生儿窒息新生儿肾小球和肾小管肾功能的评估。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Acute kidney injury (AKI) is one of the commonest manifestations of end-organ damage associated with birth asphyxia. OBJECTIVE: To evaluate glomerular and tubular dysfunction in neonates with moderate to severe birth asphyxia. DESIGN: Prospective cohort study. SETTING: Neonatal unit of a teaching hospital. METHODS: Subjects were inborn neonates of >/=34 completed weeks of gestation with an APGAR score <7 at 1 min after birth. Renal function tests including serum electrolytes were measured daily until 96 hrs of life along with urinary output. Fractional excretion of sodium (FeNa), renal failure index (RFI), urinary myoglobin and creatinine clearance (CrCl) were calculated using timed urine collection. Staging of AKI was undertaken using Acute Kidney Injury Network criteria (AKIN). PRIMARY OUTCOME MEASUREMENT: Recovery of glomerular function. RESULTS: A total of 2196 neonates were born during the study period (September 2006 to April 2007), 44 of whom met the inclusion criteria. Data from 36 neonates were available for final analysis. AKI developed in 9.1% (1/11) infants with moderate asphyxia and 56.0% (12/25) infants with severe asphyxia, making a total incidence of 41.7%. AKI persisted in 16.6% neonates at 96 hours of life. Ten neonates (27.7%) had serum creatinine levels >1.5 mg/dl. In neonates with AKI, tubular function (Fe Na, RFI, urinary myoglobin) was significantly deranged until 72-96 hrs of life. One infant died and one who was critically ill was discharged against medical advice; both had AKI. CONCLUSION: It is feasible to use AKIN staging for evaluating AKI in neonates with birth asphyxia.
机译：背景：急性肾损伤（AKI）是与出生窒息相关的终末器官损害的最常见表现之一。目的：评估中度至重度窒息新生儿的肾小球和肾小管功能障碍。设计：前瞻性队列研究。地点：教学医院的新生儿科。方法：受试者为≥34孕周的新生儿，出生后1分钟APGAR评分<7。每天进行包括血清电解质在内的肾功能检查，直至寿命96小时以及尿量。使用定时尿液收集计算出钠的部分排泄（FeNa），肾衰竭指数（RFI），尿肌红蛋白和肌酐清除率（CrCl）。使用急性肾损伤网络标准（AKIN）进行AKI分期。初步观察指标：肾小球功能恢复。结果：在研究期间（2006年9月至2007年4月），共有2196例新生儿出生，其中44例符合纳入标准。来自36名新生儿的数据可用于最终分析。 AKI在中度窒息的9.1％（1/11）婴儿和重度窒息的56.0％（12/25）婴儿中发展，总发生率为41.7％。在生命96小时内，AKI在16.6％的新生儿中持续存在。十名新生儿（27.7％）的血清肌酐水平> 1.5 mg / dl。在患有AKI的新生儿中，肾小管功能（Fe Na，RFI，尿肌红蛋白）显着紊乱直至生命72-96小时。一名婴儿死亡，一名危重病患者接受医疗建议出院;两者都有AKI。结论：采用AKIN分期评估新生儿窒息新生儿AKI是可行的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号