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首页> 外文期刊>Journal of paediatrics and child health >A 10-year retrospective survey of acute childhood osteomyelitis in Stockholm, Sweden
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A 10-year retrospective survey of acute childhood osteomyelitis in Stockholm, Sweden

机译：瑞典斯德哥尔摩急性儿童骨髓炎的10年来潮调查

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Aim Children with osteomyelitis present with a range of signs and symptoms and with varying degree of severity. The purpose of this study was to provide data on a population-based 10-year material of children with acute osteomyelitis. Methods All children, 0-14 years in Stockholm Region with acute osteomyelitis hospitalised in July 2005-June 2015, were retrospectively studied. Time to hospital presentation, disease localization, inflammation markers, imaging procedures, microbiology, severity classified by the presence of complications, surgical procedures, hospital length of stay and seasonal variation were recorded. Results There were 430 children with acute osteomyelitis; 61% were boys. The incidence per 100 000 person-years was 11.6; 9.3 in girls and 13.1 in boys. Median age at admission was 2.9 years with no peak later in childhood. Median time from first symptom to diagnosis was 4 days (range 1-21) and 48% of the cases were localised to femur or tibia. Mean C-reactive protein was 59 mg/L (range 1-376). Blood (n= 82) or tissue cultures (n= 54) were positive in 118 (28%) children. The most common pathogen wasStaphylococcus aureus(n= 88) followed byStreptococcus pyogenes(n= 12). Surgery was performed in 71 children (17%). There was no mortality. Severe complications were seen in 14 (3.3%) children, five of whom were admitted to intensive care. Median hospital length of stay was 4 days (range 1-60). Conclusions Osteomyelitis in children is a diagnostic challenge with a low yield of positive bacterial cultures. Few children with uncomplicated disease need surgery, but the risk of severe complications is not negligible.
机译：目的：儿童骨髓炎表现为一系列症状和体征，严重程度不同。本研究的目的是提供以人群为基础的10年急性骨髓炎儿童资料的数据。方法对2005年7月至2015年6月在斯德哥尔摩地区住院的所有0-14岁急性骨髓炎儿童进行回顾性研究。记录住院时间、疾病定位、炎症标志物、成像程序、微生物学、根据并发症的存在程度分类的严重程度、手术程序、住院时间和季节变化。结果430例儿童急性骨髓炎；61%是男孩。每10万人年的发病率为11.6；女孩为9.3，男孩为13.1。入院时的中位年龄为2.9岁，儿童期后期没有峰值。从首发症状到确诊的中位时间为4天（范围1-21），48%的病例局限于股骨或胫骨。平均C反应蛋白为59 mg/L（范围1-376）。118名（28%）儿童的血液（n=82）或组织培养（n=54）呈阳性。最常见的病原体是金黄色葡萄球菌（n=88），其次是化脓性链球菌（n=12）。71名儿童（17%）接受了手术。没有死亡病例。14名（3.3%）儿童出现严重并发症，其中5名儿童入院接受重症监护。平均住院时间为4天（范围1-60）。结论儿童骨髓炎是一种诊断挑战，细菌培养阳性率较低。患有简单疾病的儿童很少需要手术，但严重并发症的风险不容忽视。

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