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首页> 外文期刊>Journal of neurology >An eye-tracker controlled cognitive battery: overcoming verbal-motor limitations in ALS
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An eye-tracker controlled cognitive battery: overcoming verbal-motor limitations in ALS

机译：一种眼睛跟踪控制的认知电池：克服ALS的言语电机限制

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We assessed language, attention, executive, and social cognition abilities in a sample of patients with Amyotrophic Lateral Sclerosis (ALS) by means of a recently developed cognitive battery based on oculomotor control with eye-tracking (ET) technology. Twenty-one ALS patients and 21 age- and education-matched healthy subjects underwent the ET-based cognitive assessment, together with the standard cognitive screening tools [Frontal Assessment Battery (FAB); Montreal Cognitive Assessment (MoCA); and Digit Sequencing Task]. Psychological measures of anxiety (State-Trait Anxiety Inventory-Y) and depression (Beck Depression Inventory) were also collected, and an ET usability questionnaire was administered. For patients, clinical and respiratory examinations were also performed, together with behavioural assessment (Frontal Behavioural Inventory). The developed battery discriminated among patients and controls with regard to measures of verbal fluency, frontal abilities, and social cognition. Measures of diagnostic utility confirmed a higher diagnostic accuracy of such ET-based tests with respect to FAB; similar diagnostic accuracy emerged when comparing them to the other standard cognitive tools (MoCA, WM). Usability ratings about the ET tests were comparable among the two groups. The ET-based neuropsychological battery demonstrated good levels of diagnostic accuracy and usability in a clinical population of non-demented ALS patients, compared to matched healthy controls. Future studies will be aimed at further investigate validity and usability components by recruiting larger sample of patients, both in moderate-to-severe stages of the disease and affected by more severe cognitive impairment.
机译：我们通过最近开发的基于眼动控制（ET）技术的认知电池，评估了肌萎缩侧索硬化症（ALS）患者的语言、注意力、执行力和社会认知能力。21名ALS患者和21名年龄和教育程度匹配的健康受试者接受了基于ET的认知评估，以及标准的认知筛查工具[正面评估组合（FAB）、蒙特利尔认知评估（MoCA）和数字排序任务]。还收集了焦虑（状态-特质焦虑量表-Y）和抑郁（贝克抑郁量表）的心理测量结果，并进行了ET可用性问卷调查。对于患者，还进行了临床和呼吸检查，以及行为评估（正面行为量表）。在言语流畅性、正面能力和社会认知方面，开发的电池在患者和对照组之间存在差异。诊断效用的测量结果证实了基于ET的测试对FAB具有更高的诊断准确性；当与其他标准认知工具（MoCA、WM）进行比较时，出现了类似的诊断准确率。关于ET测试的可用性评分在两组之间具有可比性。与匹配的健康对照组相比，在非痴呆ALS患者的临床人群中，基于ET的神经心理学测试显示了良好的诊断准确性和可用性水平。未来的研究将通过招募更大样本的患者来进一步调查有效性和可用性成分，这些患者都处于疾病的中重度阶段，并且受到更严重的认知障碍的影响。

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