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首页> 外文期刊>Annals of Tropical Paediatrics >Serum cytokines in differentiating between viral and bacterial enterocolitis.
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Serum cytokines in differentiating between viral and bacterial enterocolitis.

机译：血清细胞因子可区分病毒性小肠结肠炎和细菌性小肠结肠炎。

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It is difficult to distinguish clinically between bacterial and viral causes of enterocolitis. The aim of the study was to investigate if serum cytokines can distinguish bacterial from viral enterocolitis. We prospectively enrolled 147 paediatric in-patients with acute enterocolitis. Blood was taken for leucocyte count, CRP, ESR, IL-6, IL-8, IFN-alpha and TNF-alpha on the day of admission. A pathogen was identified in 115 of the 147 children, 72 of whom had a bacterial pathogen (bacterial group) and 43 rotavirus (viral group). Mean values of the serum markers IL-6, IL-8 and CRP were significantly higher in the bacterial group. Receiver-operating characteristic curves demonstrated that a cut-off of 15 pg/ml for IL-6 had a sensitivity of 0.75 and a specificity of 0.91 for bacterial diarrhoea. Comparable values for CRP at a cut-off of 13 mg/L demonstrated a sensitivity of 0.54 and a specificity of 0.72. Values for IL-8 at a cut-off of 80 pg/ml had a sensitivity of 0.46 and a specificity of 0.71. Despite the small sample size, our data suggest that serum IL-6, IL-8 and CRP are significantly elevated in children with bacterial enterocolitis. IL-6 has a higher sensitivity, specificity and positive predictive value than IL-8 and CRP. Determination of serum cytokines might be a useful way of differentiating viral from bacterial gastro-enteritis.
机译：临床上很难区分细菌性和病毒性小肠结肠炎的原因。该研究的目的是研究血清细胞因子是否可以区分细菌与病毒性小肠结肠炎。我们预期招募了147例急性小肠结肠炎的小儿住院患者。入院当天抽取血液进行白细胞计数，CRP，ESR，IL-6，IL-8，IFN-α和TNF-α测定。在147名儿童中的115名中鉴定出病原体，其中72名患有细菌性病原体（细菌类）和43个轮状病毒（病毒组）。细菌组中血清标志物IL-6，IL-8和CRP的平均值显着较高。受体工作特性曲线表明，IL-6的临界值为15 pg / ml，对细菌性腹泻的敏感度为0.75，特异性为0.91。临界浓度为13 mg / L时CRP的可比值表明，灵敏度为0.54，特异性为0.72。截止值为80 pg / ml的IL-8值的灵敏度为0.46，特异性为0.71。尽管样本量很小，但我们的数据表明，细菌性小肠结肠炎患儿的血清IL-6，IL-8和CRP明显升高。 IL-6比IL-8和CRP具有更高的敏感性，特异性和阳性预测值。血清细胞因子的测定可能是区分病毒性细菌性胃肠炎的有用方法。

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