...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Reproductive Immunology >Effect of polybrominated diphenyl ether congeners on placental cytokine production
【24h】

Effect of polybrominated diphenyl ether congeners on placental cytokine production

机译：聚溴二苯基醚同型对胎盘性细胞因子生产的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Polybrominated diphenyl ethers (PBDEs) are pollutants that may increase the risk of preterm birth. In previous studies, we found that a mixture of PBDEs altered the expression of biomarkers for preterm birth by the placenta. However, there are 209 different PBDE congeners with different tissue distributions. How these different congeners may alter the production of immunomodulators by the placenta that help to maintain the survival of the fetal allograft is unclear. Therefore, we compared the effects 5 common congeners on basal and bacteria-stimulated cytokine production by the placenta. Placental explant cultures were incubated with 20 mu M of PBDE congeners 47, 99, 100, 153, 209 or vehicle in the presence and absence of Escherichia coli for 20 h. Conditioned medium was harvested and concentrations of IL-1 beta, TNF-alpha, IL-6, sgp130, HO-1, IL-10, BDNF, and 8-IsoP quantified. For unstimulated cultures, all congeners, except for PBDE-47, reduced the production of IL-1 beta and IL-6 production was enhanced by PBDE-153. BDNF concentrations tended to be reduced by most PBDE congeners and IL-10 production was enhanced by PBDE-99, -153, and -209. 8-IsoP production was enhanced by PBDE-153, but not the other congeners. For bacteria-stimulated cultures, PBDE-47 increased IL-1 beta production and PBDE-47, -153, and -209 tended to reduce TNF-a production. IL-6 production was enhanced by all PBDEs except 153, IL-10 production was enhanced by all congeners except for PBDE-47. All congeners significantly enhanced BDNF and 8-IsoP. These results suggest that PBDEs can alter the expression of placental biomarkers in a congener and infection-dependent manner.
机译：多溴联苯醚（PBDE）是可能增加早产风险的污染物。在以前的研究中，我们发现多溴二苯醚的混合物改变了胎盘早产生物标志物的表达。然而，有209种不同的多溴二苯醚同系物具有不同的组织分布。目前尚不清楚这些不同的同源物如何改变胎盘产生的免疫调节剂，以帮助维持胎儿同种异体移植物的存活。因此，我们比较了5种常见同系物对胎盘基础和细菌刺激的细胞因子产生的影响。胎盘外植体培养物与20μM多溴二苯醚同系物47、99、100、153、209或载体在大肠杆菌存在和不存在的情况下培养20小时。收集条件培养基，并量化IL-1β、TNFα、IL-6、sgp130、HO-1、IL-10、BDNF和8-IsoP的浓度。对于未受刺激的培养物，除PBDE-47外，所有同系物都减少了IL-1β的产生，PBDE-153提高了IL-6的产生。大多数多溴二苯醚同系物倾向于降低BDNF浓度，而多溴二苯醚-99、-153和-209则促进IL-10的产生。PBDE-153提高了8-IsoP的产量，但其他同系物没有提高。对于细菌刺激培养，PBDE-47增加IL-1β的产生，PBDE-47、-153和-209倾向于减少TNF-a的产生。除153外，所有多溴二苯醚均能促进IL-6的产生，除多溴二苯醚47外，所有同系物均能促进IL-10的产生。所有同系物均显著增强BDNF和8-IsoP。这些结果表明，多溴二苯醚可以以同源和感染依赖的方式改变胎盘生物标志物的表达。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号