Pregnancy and postpartum levels of circulating maternal sHLA-G in preeclampsia

Jacobsen Daniel P.; Lekva Tove; Moe Kjartan; Fjeldstad Heidi E. S.; Johnsen Guro Mork; Sugulle Meryam; Staff Anne Cathrine

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Pregnancy and postpartum levels of circulating maternal sHLA-G in preeclampsia

机译：妊娠和产后产后水平循环母体Shla-g在Preclampsia

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摘要

Preeclampsia is a leading cause of maternal and offspring mortality and morbidity, and predicts increased future cardiovascular disease risk. Placental dysfunction and immune system dysregulation are likely key pathophysiological factors. Soluble human leukocyte antigen G (sHLA-G) may dampen the specific immune response towards placental trophoblasts. Previous studies have shown low sHLA-G levels in preeclampsia, but postpartum, levels are unknown. Furthermore, the relationship between sHLA-G and sFlt-1 and PlGF, placental function markers, is unknown. We hypothesized that low maternal sHLA-G during pregnancy would be associated with placental dysfunction, including preeclampsia, gestational hypertension, and dysregulated sFlt-1 and PlGF, and that sHLA-G would remain decreased following preeclampsia.

机译：先兆子痫是导致母婴死亡率和发病率的主要原因，预示着未来心血管疾病风险的增加。胎盘功能障碍和免疫系统失调可能是关键的病理生理因素。可溶性人白细胞抗原G（sHLA-G）可能会抑制胎盘滋养层的特异性免疫反应。此前的研究表明，先兆子痫患者体内sHLA-G水平较低，但产后sHLA-G水平尚不清楚。此外，sHLA-G和sFlt-1以及胎盘功能标志物PlGF之间的关系尚不清楚。我们假设孕期母体sHLA-G水平较低与胎盘功能障碍有关，包括先兆子痫、妊娠高血压、sFlt-1和PlGF失调，且先兆子痫后sHLA-G水平仍将降低。

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来源
《Journal of Reproductive Immunology》 |2021年第1期|共7页
作者
Jacobsen Daniel P.; Lekva Tove; Moe Kjartan; Fjeldstad Heidi E. S.; Johnsen Guro Mork; Sugulle Meryam; Staff Anne Cathrine;
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作者单位

Oslo Univ Hosp Div Obstet &

Gynaecol Oslo Norway;

Oslo Univ Hosp Res Inst Internal Med Oslo Norway;

Oslo Univ Hosp Div Obstet &

Gynaecol Oslo Norway;

Oslo Univ Hosp Div Obstet &

Gynaecol Oslo Norway;

Oslo Univ Hosp Div Obstet &

Gynaecol Oslo Norway;

Oslo Univ Hosp Div Obstet &

Gynaecol Oslo Norway;

Oslo Univ Hosp Div Obstet &

Gynaecol Oslo Norway;

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原文格式 PDF
正文语种 eng
中图分类妇科学;
关键词
sHLA-G; Preeclampsia; sFlt-1; PlGF; Immunology; Angiogenic biomarkers;

机译：sHLA-G;子痫前期;sFlt-1;PlGF;免疫学;血管生成生物标志物;

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4. The effect of the D1-C785T polymorphism in the type 1 iodothyronine deiodinase gene on the circulating thyroid hormone levels in Romanian women with preeclampsia. Association with the degree of severity and pregnancy outcome of preeclampsia [J] . ProcopciucL.M., HaziG.M., CaracosteaG., Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology . 2012,第5期

机译：1型碘甲状腺素去碘酶基因D1-C785T多态性对罗马尼亚先兆子痫妇女的循环甲状腺激素水平的影响。与子痫前期的严重程度和妊娠结局相关
5. Analysis of changes in maternal circulating angiogenic factors throughout pregnancy for the prediction of preeclampsia [J] . Honigberg M. C., Cantonwine D. E., Thomas A. M., Journal of perinatology: Official journal of the California Perinatal Association . 2016,第3期

机译：整个妊娠期间母体循环血管生成因子的变化分析，以预测先兆子痫
6. Circulating angiogenic factors and risk of adverse maternal and perinatal outcomes in twin pregnancies with suspected preeclampsia [J] . RanaS., HackerM.R., ModestA.M., Hypertension: An Official Journal of the American Heart Association . 2012,第2期

机译：怀疑患有先兆子痫的双胎妊娠中循环血管生成因子和对母体和围产儿不良后果的风险
7. Maternal exposure to high levels of magnetic field non-ionizing radiation during pregnancy and the risk of preeclampsia: A large prospective cohort study [C] . De-Kun Li, Hong Chen, Jeannette Ferber, Joint Meeting of the Bioelectromagnetics Society and the European BioElectromagnetics Association . 2018

机译：孕妇暴露于妊娠期间高水平的磁场非电离辐射和预普拉姆斯的风险：大型前瞻性队列研究
8. Maternal Circulating Immune Factors and Fetal Growth: C-Reactive Protein, Tumor Necrosis Factor - α, Interleukin - 6, in Mid-Pregnancy and Birthweight for Gestational Age [D] . Glazier-Essalmi, Alicynne N. 2020

机译：孕产妇循环免疫因子和胎儿生长：C反应蛋白，肿瘤坏死因子 - α，白细胞介素-6，中期妊娠和孕龄的分批
9. First-Trimester Levels of Pregnancy-Associated Plasma Protein A2 (PAPP-A2) in the Maternal Circulation Are Elevated in Pregnancies That Subsequently Develop Preeclampsia [O] . Erin J. Crosley, Ursula Durland, Ken Seethram, -1

机译：孕期孕妇妊娠相关血浆蛋白A2（PAPP-A2）的前三个月水平在随后发展为先兆子痫的妊娠中升高。
10. Pregnancy and postpartum levels of circulating maternal sHLA-G in preeclampsia [O] . Daniel P. Jacobsen, Tove Lekva, Kjartan Moe, 2021

机译：妊娠期孕妇孕产妇SHLA-G的妊娠和产后水平
11. Elevated Ratio of Maternal Plasma ApoCIII to ApoCII in Preeclampsia. [R] . Flood-Nichols, S. K., Stallings, J. D., Gotkin, J. L., 2011

机译：先兆子痫中母体血浆apoCIII与apoCII的升高比例。

Pregnancy and postpartum levels of circulating maternal sHLA-G in preeclampsia

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