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Iatrogenic Oral Ketamine Overdose in Palliative Care

机译:姑息治疗中的性能口服氯胺酮过量

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Background: Optimal pain management in the palliative care setting often requires multiple pharmacological interventions including novel and off-label therapies. Ketamine is an anesthetic agent with increasing evidence supporting its use for pain. Through N-methyl-d-aspartate antagonism and activity at opioid receptors, it is an adjuvant to traditional analgesics with the benefit of being opioid sparing. Ketamine has a wide safety profile with limited reports of overdose. Little is published on supratherpeutic dosing in the pain setting.
机译:背景:姑息治疗环境下的最佳疼痛管理通常需要多种药物干预,包括新颖和非标签疗法。氯胺酮是一种麻醉剂,越来越多的证据支持其用于止痛。通过N-甲基-d-天冬氨酸拮抗作用和阿片受体活性,它是传统镇痛剂的佐剂,具有保留阿片类物质的优点。氯胺酮具有广泛的安全性,但过量的报告有限。很少有关于疼痛环境下的超治疗剂量的报道。

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