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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Brachial-Ankle Pulse Wave Velocity is Related to the Total Cerebral Small-Vessel Disease Score in an Apparently Healthy Asymptomatic Population
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Brachial-Ankle Pulse Wave Velocity is Related to the Total Cerebral Small-Vessel Disease Score in an Apparently Healthy Asymptomatic Population

机译：肱骨脉搏波速度与显着健康无症状人群的总脑小血管疾病得分有关

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Introduction: Cerebral small-vessel disease (CSVD) is an extensive cerebrovascular disease associated with many poor outcomes. Previous studies have shown that brachial-ankle pulse wave velocity (baPWV) is related to various neuroimaging signatures, but its association with the total CSVD burden remains unknown. We aimed to explore whether baPWV is related to the total CSVD score and to establish a cutoff for detecting the presence and severity of CSVD, which may guide clinical preventive measures. Methods: We retrospectively selected 684 neurologically healthy participants to explore correlations between baPWV and the total CSVD score and each of its components (lacunes, white matter hyperintensity (WMH), perivascular space (PVS), and cerebral microbleeds (CMBs)). Subsequently, we established two receiver operating characteristic (ROC) curves to study the effectiveness of baPWV in predicting CSVD (scores 1-4) and severe CSVD (scores 3-4). Results: The median baPWV was 13.16 m/s, which increased significantly with increasing scores (0-4). BaPWV was significantly higher among persons with each component of the total CSVD score than among those without any components. Multivariable ordinal logistic regression analyses showed that a one-unit (m/s) change in baPWV significantly increased the total CSVD score by 0.012. The optimal baPWV cutoffs for detecting CSVD and severe CSVD were 13.12 m/s and 15.63 m/s, respectively. Conclusions: BaPWV was positively correlated with the total CSVD score, suggesting that baPWV measurement is a useful method for early diagnosis of CSVD, which may contribute to preventing and controlling CSVD progression in the general population of China.
机译：导言：脑小血管病（CSVD）是一种广泛的脑血管疾病，预后不佳。以往的研究表明，肱踝脉搏波速度（baPWV）与各种神经影像学特征有关，但其与CSVD总负荷的关系尚不清楚。我们的目的是探讨baPWV是否与CSVD总分相关，并建立检测CSVD的存在和严重程度的临界值，这可能指导临床预防措施。方法：我们回顾性选择684名神经健康受试者，探讨baPWV与CSVD总分及其各组成部分（腔隙、白质高信号（WMH）、血管周围间隙（PVS）和脑微出血（CMBs）之间的相关性。随后，我们建立了两条受试者操作特征（ROC）曲线，以研究baPWV预测CSVD（得分1-4）和严重CSVD（得分3-4）的有效性。结果：baPWV中位数为13.16 m/s，随着得分的增加（0-4）显著增加。有CSVD总分各分量的人的BaPWV显著高于无任何分量的人。多变量有序logistic回归分析显示，baPWV的一个单位（m/s）变化显著增加CSVD总分0.012。检测CSVD和严重CSVD的最佳baPWV阈值分别为13.12 m/s和15.63 m/s。结论：BaPWV与CSVD总分呈正相关，提示BaPWV检测是CSVD早期诊断的有效方法，有助于预防和控制中国人群CSVD的进展。

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