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首页> 外文期刊>International heart journal >Impact of combined assessment of coronary artery calcium score, carotid artery plaque score, and brachial-ankle pulse wave velocity for early coronary revascularization in patients with suspected coronary artery disease.
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Impact of combined assessment of coronary artery calcium score, carotid artery plaque score, and brachial-ankle pulse wave velocity for early coronary revascularization in patients with suspected coronary artery disease.

机译：合并评估冠状动脉钙化评分，颈动脉斑块评分和臂踝脉搏波速度对疑似冠心病患者早期冠脉血运重建的影响。

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Coronary artery calcium score (CACS) measured by multi-detector computed tomography, carotid plaque score (CPS) measured by carotid artery ultrasound, and brachial-ankle pulse wave velocity (baPWV) are noninvasive screening tools for coronary artery disease. The aim of this study was to determine whether the combination of CACS, CPS, and baPWV improves the prognostic value for future cardiac events. CACS, CPS, and baPWV were assessed in 77 patients (mean age, 65 years, 49 males) undergoing invasive coronary angiography. ECG-triggered MSCT was used to assess CACS. CPS was defined as the sum of all plaque heights in bilateral carotid arteries. The highest baPWV was used for analysis. Cardiac events were defined as cardiac death, nonfatal myocardial infarction, or coronary revascularization. Thirty-two cardiac events (41.6%) occurred during follow-up (23.6 ± 20.8 months), consisting of 28 PCIs and 4 CABGs. The best cutoff values of positive CACS, CPS, and baPWV for predicting cardiac events were ≥ 50, ≥ 5, and ≥1.6 m/second, respectively. For the combination of the 3 modalities, the positive test was defined as having at least 1 positive result by each method. The negative predictive value of all 3 modalities combined was better than that of CACS alone. The event-free rate was higher in patients with negative results for all 3 parameters compared with those that were positive (100% versus 44.8%, P < 0.0001). The prognostic value of using combined assessment of CACS, CPS, and baPWV is more effective for predicting cardiac events than CACS alone.
机译：通过多探测器计算机断层扫描术测量的冠状动脉钙评分（CACS），通过颈动脉超声测量的颈动脉斑块评分（CPS）和臂踝脉搏波速度（baPWV）是冠状动脉疾病的非侵入性筛查工具。这项研究的目的是确定CACS，CPS和baPWV的组合能否改善未来心脏事件的预后价值。在接受侵入性冠状动脉造影的77例患者（平均年龄，65岁，49位男性）中评估了CACS，CPS和baPWV。使用ECG触发的MSCT评估CACS。 CPS被定义为双侧颈动脉所有斑块高度的总和。最高的baPWV用于分析。心脏事件定义为心脏死亡，非致命性心肌梗塞或冠状动脉血运重建。在随访期间（23.6±20.8个月）发生了32例心脏事件（41.6％），包括28个PCI和4个CABG。 CACS，CPS和baPWV阳性预测心脏事件的最佳截止值分别为≥50，≥5和≥1.6 m / sec。对于这三种模式的组合，将阳性测试定义为每种方法至少具有1个阳性结果。所有这三种方式的阴性预测值均优于单独的CACS。在所有三个参数均阴性的患者中，无事件发生率高于阳性参数（100％对44.8％，P <0.0001）。与单独使用CACS相比，结合使用CACS，CPS和baPWV评估的预后价值更有效地预测心脏事件。

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