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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Time of Stroke Onset in Coronavirus Disease 2019 Patients Around the Globe: A Systematic Review and Analysis
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Time of Stroke Onset in Coronavirus Disease 2019 Patients Around the Globe: A Systematic Review and Analysis

机译：在全球冠状病毒疾病2019年患者中脑卒中的时间：系统审查和分析

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Introduction: Coronavirus disease 2019 has been associated with stroke, particular characteristics of these patients are not fully understood. The adequate management of these patients depends on the comprehension of factors such as temporality, clinical presentation and etiology. We hypothesize there is an important temporal relationship between COVID-19 severity and stroke onset. Methods: a systematic review of the available literature was conducted using Pubmed and Scopus, studies reporting patients with Coronavirus disease 19 and stroke were included. Clinical, sociodemographic and laboratory characteristics of patients were extracted and analyzed. Results: Forty-seven studies and 176 patients were included, with a mean age of 63.1 years (SD=16 n=122), most of them were males (63.2% n=171). The most frequent etiology was cryptogenic 40.9% n=66), and a mean National Institute of Health Stroke Scale of 14.4 points was found (SD=8.6 n=73). Large vessel occlusion was reported in 65.9% patients (n=91) and these patients were younger with greater stroke severity. D-dimer, C-reactive protein, fibrinogen, ferritin and lactate dehydrogenase were elevated in most patients with reported findings. Most patients had severe Coronavirus disease 2019. The mean time from onset of respiratory symptoms to stroke was 9 days (SD=9.9), the shortest time was noted in those with mild and moderate disease. Conclusions: There is a trend between the severity of Coronavirus disease 2019 and time to stroke onset. Also, age and stroke severity were found to be related to the development of large vessel occlusion. Inflammation and hypercoagulability markers are elevated in this disease, we propose to not discard hypercoagulability secondary to severe acute respiratory syndrome-coronavirus-2 as an underlying cause of stroke in these patients.
机译：导言：2019年的冠状病毒病与中风有关，这些患者的特殊特征尚未完全了解。对这些患者的适当管理取决于对时间性、临床表现和病因等因素的理解。我们假设2019冠状病毒疾病严重程度与卒中发病之间有重要的时间关系。方法：使用Pubmed和Scopus对现有文献进行系统回顾，包括报道冠状病毒病19和中风患者的研究。提取并分析患者的临床、社会人口学和实验室特征。结果：纳入47项研究和176名患者，平均年龄63.1岁（SD=16，n=122），其中大部分为男性（63.2%，n=171）。最常见的病因是隐源性中风（40.9%（n=66），美国国家卫生研究院卒中量表的平均分为14.4分（SD=8.6，n=73）。据报道，65.9%的患者（n=91）出现大血管闭塞，这些患者年龄较小，卒中严重程度较高。在报告的大多数患者中，D-二聚体、C-反应蛋白、纤维蛋白原、铁蛋白和乳酸脱氢酶升高。大多数患者患有严重的冠状病毒病。从出现呼吸系统症状到中风的平均时间为9天（SD=9.9），轻中度疾病患者的时间最短。结论：2019年冠状病毒病的严重程度与中风发病时间之间存在趋势。此外，发现年龄和中风严重程度与大血管闭塞的发展有关。炎症和高凝状态标志物在本病中升高，我们建议不要放弃严重急性呼吸综合征冠状病毒-2继发的高凝状态作为这些患者卒中的潜在原因。

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