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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Prediction of Recovery and Outcome Using Motor Evoked Potentials and Brain Derived Neurotrophic Factor in Subacute Stroke
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Prediction of Recovery and Outcome Using Motor Evoked Potentials and Brain Derived Neurotrophic Factor in Subacute Stroke

机译：利用电动机诱发电位和脑源性脑卒中的神经营养因子预测回收和结果

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Introduction and Objectives: Motor evoked potentials (MEPs) have been postulated to be useful in predicting recovery in patients with motor impairment. We aimed to investigate whether MEPs elicited by transcranial magnetic stimulation (TMS), serum brain derived neurotrophic factor (BDNF) and its genotype have prognostic value on stroke recovery in patients with hand paresis due to stroke. Methods: This was an observational cohort study. Patients underwent TMS with MEPs from abductor digiti minimi evaluation between 2-14 (D0) and 30 days (D30) after stroke and their impact on motor function of the upper limb and general outcome was assessed after 3 months (D90). The presence of a BDNF gene polymorphism was determined and serum BDNF concentrations were measured at D0, D30 and D90. Results: The presence of MEPs and their amplitude at rest and in effort significantly correlated with improvement of upper-limb paresis and general outcome after 3 months. Resting motor threshold did not have prognostic value. Central motor conduction time and MEP latency less consistently predicted stroke outcome or motor deficit improvement. Neither BDNF polymorphisms nor BDNF concentration at D0, D30 and D90 corresponded with the degree of paresis or the independence of patients 3 months after stroke. Conclusions: The presence of MEPs and their amplitude are useful predictors of upper-limb motor function recovery and general outcome after stroke. BDNF concentration and its genotype had no prognostic value. Further studies conducted on large cohorts are necessary to determine the usefulness of these methods in motor recovery and stroke outcome prediction.
机译：导言和目的：运动诱发电位（MEPs）被认为对预测运动障碍患者的康复是有用的。我们的目的是研究经颅磁刺激（TMS）、血清脑源性神经营养因子（BDNF）及其基因型诱导的MEP是否对中风所致手部轻瘫患者的中风恢复有预后价值。方法：这是一项观察性队列研究。患者在中风后2-14天（D0）和30天（D30）之间接受TMS和MEPs评估，并在3个月（D90）后评估其对上肢运动功能和总体预后的影响。检测BDNF基因多态性的存在，并在D0、D30和D90测量血清BDNF浓度。结果：3个月后，MEP的存在及其在静止和用力时的振幅与上肢轻瘫的改善和总体预后显著相关。静息运动阈值没有预后价值。中枢运动传导时间和MEP潜伏期对卒中结局或运动缺陷改善的预测不一致。BDNF多态性和D0、D30和D90的BDNF浓度均与中风后3个月患者的轻瘫程度或独立性不相关。结论：MEP的存在及其振幅是预测中风后上肢运动功能恢复和总体预后的有用指标。BDNF浓度及其基因型无预后价值。为了确定这些方法在运动恢复和中风预后预测中的有用性，有必要对大型队列进行进一步研究。

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