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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >A Prehospital Acute Stroke Trial has Only Modest Impact on Enrollment in Concurrent, Post-arrival-Recruiting Stroke Trials
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A Prehospital Acute Stroke Trial has Only Modest Impact on Enrollment in Concurrent, Post-arrival-Recruiting Stroke Trials

机译：急性急性中风审判对同时入学，到达后招聘卒中试验只有适度的影响

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摘要

Background: Because "time is brain," acute stroke trials are migrating to the prehospital setting. The impact upon enrollment in post-arrival trials of earlier recruitment in a prehospital trial requires delineation. Methods: We analyzed all patients recruited into acute and prevention stroke trials during an 8-year period when an academic medical center (AMC) was participating in a prehospital treatment trial - the NIH Field Administration of Stroke Treatment - Magnesium (FAST-MAG) study. Results: During the study period, in addition to FAST-MAG, the AMC participated in 33 post-arrival stroke trials: 27 for acute cerebral ischemia, one for intracerebral hemorrhage, and 5 secondary prevention trials. Throughout the study period, the AMC was recruiting for at least 3 concurrent post-arrival acute trials. Among 199 patients enrolled in acute stroke trials, 98 (49%) were in FAST-MAG and 101 (51%) in concurrent, post-arrival acute trials. Among FAST-MAG patients, 67% were not eligible for any concurrent acute, post-arrival trial. Of 134 patients eligible for post-arrival acute trials, 101 (76%) were enrolled in post-arrival trials and 32 (24%) in FAST-MAG. Leading reasons FAST-MAG patients were ineligible for post-arrival acute trials were: NIHSS too low (23.4%), intracranial hemorrhage (17.9%), IV tPA used in standard management (9.0%), NIHSS too high (7.1%), and age too high (5.2%). Conclusions: A prehospital hyperacute stroke trial with wide entry criteria reduced only modestly, by one-fourth, enrollment into concurrently active, post-arrival stroke trials. Simultaneous performance of prehospital and post-arrival acute and secondary prevention stroke trials in research networks is feasible.
机译：背景：因为“时间就是大脑”，急性中风试验正在转移到院前环境。院前试验中早期招募对抵达后试验注册的影响需要界定。方法：我们分析了在学术医学中心（AMC）参与院前治疗试验（NIH中风治疗现场管理-镁（FAST-MAG）研究的8年期间，所有被纳入急性和预防中风试验的患者。结果：在研究期间，除FAST-MAG外，AMC还参与了33项到达后卒中试验：27项急性脑缺血试验、1项脑出血试验和5项二级预防试验。在整个研究期间，AMC招募了至少3名同时进行的抵达后急性试验。在参加急性卒中试验的199名患者中，98名（49%）患者参加了FAST-MAG试验，101名（51%）患者参加了同时进行的到达后急性试验。在FAST-MAG患者中，67%的患者没有资格同时进行任何急性到达后试验。在134名符合抵达后急性试验条件的患者中，101名（76%）参与了抵达后试验，32名（24%）参与了FAST-MAG。FAST-MAG患者不符合抵达后急性试验条件的主要原因是：NIHSS过低（23.4%）、颅内出血（17.9%）、标准管理中使用的静脉tPA（9.0%）、NIHSS过高（7.1%）和年龄过高（5.2%）。结论：一项具有广泛进入标准的院前超急性中风试验，在同时进行的、到达后的中风试验中，登记人数仅略微减少了四分之一。在研究网络中同时进行院前和到达后急性和二级预防中风试验是可行的。

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