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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Serum Neuropeptide Y Level is Associated with Post-Ischemic Stroke Epilepsy
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Serum Neuropeptide Y Level is Associated with Post-Ischemic Stroke Epilepsy

机译：血清神经肽Y水平与缺血性卒中癫痫有关

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Background and purpose: Post-ischemic stroke epilepsy (PISE) is one of the common complications of stroke. Materials and methods: Methods To determine the risk factors of PISE, in this study, 78 patients with PISE and 86 patients without PISE were recruited. Clinical data and serum neuropeptide Y (NPY) levels were collected and the relative factors including clinical data and serum were analyzed. Results: Logistic regression showed that low serum NPY was significantly associated with PISE. Every 5 ng/ml increment of serum NPY was associated with 62% risk decrease in patients with PISE. The area under curve of serum NPY was 0.910 with a sensitivity of 84.62% and a specificity of 86.05%. The cut-off value of serum NPY was 90 ng/ml. According to cut-off value of serum NPY, the percentage of patients with PISE decreased from 84.6% in low serum NPY group to 14.0% in high serum NPY group. Furthermore, patients were divided into different tertiles according to serum NPY. The percentage of patients with PISE reduced from 90.0% in the lowest tertile (NPY = 105 ng/ml). Compared with patients with normal video-electroencephalogram (VEEG), serum NPY levels significantly decreased in patients with abnormal VEEG; however, serum NPY levels were not associaated with epileptic seizure subtypes. Conclusions: Serum NPY was an independent risk factor for PISE. Targeting serum NPY may be used to the prevention and treatment of PISE.
机译：背景与目的：缺血性卒中后癫痫（PISE）是脑卒中常见的并发症之一。材料和方法：为确定PISE的危险因素，本研究招募了78例PISE患者和86例非PISE患者。收集临床资料和血清神经肽Y（NPY）水平，并分析相关因素，包括临床资料和血清。结果：Logistic回归分析显示，低血清NPY与PISE显著相关。PISE患者血清NPY每增加5ng/ml，风险降低62%。血清NPY曲线下面积为0.910，敏感性为84.62%，特异性为86.05%。血清NPY的临界值为90ng/ml。根据血清NPY的临界值，PISE患者的百分比从低血清NPY组的84.6%降至高血清NPY组的14.0%。此外，根据血清NPY将患者分为不同的三组。PISE患者的百分比从最低三分位数（NPY=105 ng/ml）的90.0%下降。与正常视频脑电图（VEEG）患者相比，VEEG异常患者的血清NPY水平显著降低；然而，血清NPY水平与癫痫发作亚型无关。结论：血清NPY是PISE的独立危险因素。靶向血清NPY可用于PISE的预防和治疗。

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