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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Remote Ischemic Post-Conditioning may Improve Post-Stroke Cognitive Impairment: A Pilot Single Center Randomized Controlled Trial
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Remote Ischemic Post-Conditioning may Improve Post-Stroke Cognitive Impairment: A Pilot Single Center Randomized Controlled Trial

机译：远程缺血后调节可能会改善行程后的认知障碍：试点单中心随机对照试验

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Background and Purpose: We aimed to demonstrate the tolerability and feasibility and the effect of remote ischemic post-conditioning on cognitive functioning in patients with post-stroke cognitive impairment. Methods: This was a single-center, randomized, outcome-blinded, placebo-controlled trial, randomized 1:1 to receive 4 cycles of remote ischemic post-conditioning or a sham procedure for 7 days. The primary outcome measure was tolerability and feasibility of remote ischemic post-conditioning. Secondary outcomes to measure the neurological function with national institute of health stroke scale and the cognitive impairment with Montreal Cognitive Assessment scale and Alzheimer's disease assessment scale-cognitive (at baseline, 90 days, 180 days). Results: 48 patients (24 RIPC and 24 Control) were recruited. remote ischemic post-conditioning was well tolerated with 90 out of 96 cycles completed in full. 4 patients experienced vascular events in the control group: 3 cerebrovascular and 1 cardiovascular event versus only 2 cerebrovascular events in the RIPC group. We showed the similar result in the neurological function with national institute of health stroke scale score with no statistically significant differences between RIPC and control group at baseline (P = 0.796) and 90 days (P = 0.401) and 180 days (P = 0.695). But compare with baseline, it was significantly difference in the control and RIPC group at 90 days (P 0.05 at baseline which was no statistical difference, but P 0.05 at baseline (P = 0.955) and 90 days (P = 0.138) was no statistical difference, but P = 0.005 <0.05 at 180 days was significant statistical difference. Conclusions: The remote ischemic post-conditioning for post-stroke cognitive impairment was well tolerated, safe and feasible. The remote ischemic post-conditioning may improve neurological and cognitive outcomes in patients with post-stroke cognitive impairment. A larger trial is warranted.
机译：背景和目的：我们旨在证明远程缺血后处理对卒中后认知障碍患者认知功能的耐受性、可行性和影响。方法：这是一项单中心、随机、结果盲、安慰剂对照试验，随机1:1，接受4个周期的远程缺血后处理或假手术7天。主要观察指标是远程缺血后处理的耐受性和可行性。使用国家卫生研究院卒中量表测量神经功能的次要结果，以及使用蒙特利尔认知评估量表和阿尔茨海默病认知评估量表测量认知障碍的次要结果（基线检查时，90天，180天）。结果：招募了48名患者（24名RIPC患者和24名对照患者）。远程缺血后处理耐受性良好，96个周期中有90个完全完成。对照组有4名患者发生血管事件：3例脑血管事件和1例心血管事件，而RIPC组只有2例脑血管事件。我们在神经功能方面的结果与美国国家卫生研究院卒中量表评分相似，在基线检查（P=0.796）、90天（P=0.401）和180天（P=0.695）时，RIPC组和对照组之间没有统计学显著差异。但与基线相比，对照组和RIPC组在90天时有显著差异（基线时P0.05，无统计学差异，但基线时P0.05（P=0.955）和90天（P=0.138）无统计学差异，但180天时P=0.005<0.05，有显著统计学差异。结论：脑卒中后认知功能障碍的远程缺血后处理耐受性好，安全可行。远程缺血后处理可能改善卒中后认知障碍患者的神经和认知结果。更大规模的审判是必要的。

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