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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Aging Changes of Aneurysmal Subarachnoid Hemorrhage: A 35-year, Hospital-Based Study
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Aging Changes of Aneurysmal Subarachnoid Hemorrhage: A 35-year, Hospital-Based Study

机译：动脉瘤性蛛网膜下腔出血的老化变化：35年，医院研究

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摘要

Background: The etiology and background factors which cause decreases in the size of ruptured intracranial aneurysms remain unclear. Objective: To clarify the age- and sex-related differences in aneurysmal subarachnoid hemorrhage (SAH) based on a 35-year-old hospital database and demographic data. Methods: A database of patients admitted to our hospital with aneurysmal SAH from 1983 to 2017 was split into 5-year intervals and analyzed. Demographic data of the general population were also analyzed for reference. Results: Altogether, 1,523 aneurysmal SAH events were enrolled in the analysis. Age (p = 65 years old (p<0.001), female sex (p=0.005), very small aneurysms less than 5 mm (p<0.001), and the yearly-averaged number of fatal events showed increasing trends. The proportion of aneurysm size of 10 mm or more (p = 0.011) and the yearly-averaged population of Shimane prefecture (p < 0.001) showed declining trends. In the subgroup analyses, the proportion of very small aneurysms was found to increase significantly in the non-elderly male and elderly female subgroups. The proportion of large aneurysms (10 mm or more) decreased in the nonelderly subgroup (p<0.05). As for the elderly subgroups, the yearly-averaged number of events did not show a significant tendency, although the yearly-averaged population of Shimane prefecture showed an increasing trend. Conclusion: We found an increasing trend in the prevalence of very small aneurysms in elderly females. Recent aging may contribute to this trend. The number of aneurysmal SAH events was confirmed to not increase, despite the increased aging population of Shimane prefecture.
机译：背景：导致破裂颅内动脉瘤大小减小的病因和背景因素尚不清楚。目的：根据35年的医院数据库和人口统计学数据，阐明动脉瘤性蛛网膜下腔出血（SAH）的年龄和性别差异。方法：将1983年至2017年我院收治的动脉瘤性蛛网膜下腔出血患者的数据库分为5年进行分析。还分析了一般人口的人口统计数据，以供参考。结果：共有1523例动脉瘤性蛛网膜下腔出血纳入分析。年龄（p=65岁（p<0.001）、女性（p=0.005）、小于5mm的非常小的动脉瘤（p<0.001）以及年平均死亡事件数呈上升趋势。动脉瘤大小大于等于10 mm（p=0.011）和岛根县年平均人口比例（p<0.001）呈下降趋势。在亚组分析中，发现非老年男性和老年女性亚组中非常小的动脉瘤的比例显著增加。非老年组大动脉瘤（10mm或以上）的比例降低（p<0.05）。至于老年人亚组，尽管岛根县的年平均人口呈上升趋势，但年平均事件数没有表现出显著的趋势。结论：我们发现老年女性微小动脉瘤的患病率呈上升趋势。最近的老龄化可能促成了这一趋势。尽管岛根县人口老龄化增加，但动脉瘤性SAH事件的数量并未增加。

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