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首页> 外文期刊>Journal of the advanced practitioner in oncology >Metastatic Melanoma With Leptomeningeal Disease
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Metastatic Melanoma With Leptomeningeal Disease

机译：具有髓鞘疾病的转移性黑色素瘤

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Leptomeningeal disease in patients with melanoma historically portends a grim prognosis, with median survival measured in weeks to months. The advent of effective immunotherapy and targeted agents may modify the outcome of such patients. This case report describes a 43-year-old patient diagnosed with stage Illa BRAF-positive cutaneous melanoma in 2012 who subsequently developed leptomeningeal involvement as her sole site of melanotic metastasis. She received multiple systemic therapies and radiotherapy and survived 2.5 years after her diagnosis with central nervous system involvement. This case report highlights the importance of a multidisciplinary team and the advent of effective agents, which offers the potential for significantly improved outcomes for patients with metastatic melanoma involving the central nervous system.
机译：黑色素瘤患者的软脑膜疾病历来预示着糟糕的预后，中位生存期以周到月为单位。有效的免疫疗法和靶向药物的出现可能会改变这类患者的预后。本病例报告描述了一名43岁的患者，2012年被诊断为阶段性BRAF阳性皮肤黑色素瘤，随后发展为软脑膜受累，这是她唯一的黑色素转移部位。她接受了多种全身治疗和放疗，并在诊断为中枢神经系统受累后存活了2.5年。本病例报告强调了多学科团队的重要性和有效药物的出现，这为涉及中枢神经系统的转移性黑色素瘤患者提供了显著改善预后的可能性。

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