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首页> 外文期刊>Journal of the advanced practitioner in oncology >Revisiting Infectious Complications Following Total Parenteral Nutrition Use During Hematopoietic Stem Cell Transplantation
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Revisiting Infectious Complications Following Total Parenteral Nutrition Use During Hematopoietic Stem Cell Transplantation

机译：在造血干细胞移植过程中促进肠外营养使用后重新发现传染性并发症

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Background: Total parenteral nutrition (TPN) is frequently used to manage caloric needs during hematopoietic stem cell transplantation (HSCT). Previous studies in transplant patients who received TPN have reported widely discordant results with regard to infection and mortality, and risk factors for TPN-related infection remain unclear. Method: We conducted a retrospective study of all HSCT recipients treated with TPN between 2005 to 2014 at Northwestern Memorial Hospital to determine the incidence and epidemiology of infections. Electronic records were used to identify patients treated with TPN for at least 2 days who developed infection. Results: Among 198 patients treated with TPN, 30% developed documented infection. Total parenteral nutrition treatment duration (13 vs. 7 days; p < .0001) and the timing of TPN initiation (> day 9 post HSCT; p < .0001) were significantly higher in patients who received TPN and developed infection. Receipt of an allogeneic transplant was associated with increased risk for infection (p < .0138), and day 60 mortality was significantly higher in TPN-treat-ed patients with infection (p < .0001). Conclusion: Stem cell recipients who receive TPN, especially from an allogeneic donor, have high rates of infection and mortality. Minimizing TPN exposure may reduce the chance for infection.
机译：背景：在造血干细胞移植（HSCT）过程中，全肠外营养（TPN）经常用于控制热量需求。之前对接受TPN的移植患者进行的研究报告在感染和死亡率方面存在广泛的不一致性，TPN相关感染的风险因素尚不清楚。方法：我们对2005年至2014年间在西北纪念医院接受TPN治疗的所有HSCT受者进行了回顾性研究，以确定感染的发病率和流行病学。电子记录用于确定接受TPN治疗至少2天的患者是否感染。结果：在接受TPN治疗的198名患者中，30%的患者出现了记录在案的感染。在接受TPN并发生感染的患者中，总的肠外营养治疗持续时间（13天比7天；p<0.0001）和TPN开始的时间（HSCT后>9天；p<0.0001）显著较高。接受同种异体移植与感染风险增加相关（p<0.0138），TPN治疗的ed感染患者第60天死亡率显著较高（p<0.0001）。结论：接受TPN的干细胞受者，尤其是来自异基因供体的干细胞受者，感染率和死亡率较高。尽量减少TPN接触可能会减少感染的机会。

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