...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Annals of tropical medicine and parasitology >Antifilarial drugs, in the doses employed in mass drug administrations by the Global Programme to Eliminate Lymphatic Filariasis, reverse lymphatic pathology in children with Brugia malayi infection.
【24h】

Antifilarial drugs, in the doses employed in mass drug administrations by the Global Programme to Eliminate Lymphatic Filariasis, reverse lymphatic pathology in children with Brugia malayi infection.

机译：按照全球消除淋巴丝虫病计划大规模药物给药的剂量使用的抗丝虫药物可逆转马来氏布鲁氏菌感染儿童的淋巴病理学。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Lymphatic filariasis is increasingly viewed as the result of an infection that is often acquired in childhood. The lymphatic pathology that occurs in the disease is generally believed to be irreversible. In a recent study in India, Doppler ultrasonography and lymphoscintigraphy were used to explore subclinical pathology in 100 children from an area endemic for Brugia malayi infection. All the children investigated showed some evidence of current or previous filarial infection. Some were microfilaraemic but asymptomatic, some were amicrofilaraemic but had filarial disease or a past history of microfilaraemia and/or filarial disease, and the rest, though amicrofilaraemic, asymptomatic and without any history of microfilaraemia or filarial disease, were seropositive for antifilarial IgG(4) antibodies. All the children were treated every 6 months, with a single combined dose of diethylcarbamazine (6 mg/kg) and albendazole (400 mg), and followed up for 24 months. By the end of this period all but one of the children were amicrofilaraemic and the 'filarial dance sign' could not be detected in any of the 14 children who had initially been found positive for this sign. Although lymphoscintigraphy revealed lymph-node and lymph-vessel damage in 82% of the children at enrolment, in about 67% of the children this pathology was markedly reduced by the 24-month follow-up. These results indicate that the drug regimens used in the mass drug administrations run by the Global Programme to Eliminate Lymphatic Filariasis are capable of reversing subclinical lymphatic damage and can provide benefits other than interruption of transmission in endemic areas. The implications of these findings are presented and discussed.
机译：淋巴丝虫病越来越多地被认为是儿童期感染的结果。通常认为该疾病中发生的淋巴病理学是不可逆的。在印度的一项最新研究中，多普勒超声检查和淋巴闪烁成像技术被用于探索100例来自马来西亚马来虫感染流行地区的儿童的亚临床病理学。所有接受调查的儿童均显示出当前或以前的丝虫感染的一些证据。有些是微丝虫病但无症状，有些是微丝虫病但有丝虫病或既往有微丝虫病和/或丝虫病病史，其余为无丝虫病，无症状且无任何丝虫病或丝虫病史，对抗丝虫IgG呈血清反应阳性（4 ）抗体。所有儿童每6个月接受一次联合剂量的二乙基卡巴嗪（6 mg / kg）和阿苯达唑（400 mg）的治疗，并随访24个月。到这一时期结束时，除一名儿童外，其余所有儿童均为微丝虫病，在最初被发现对该体征呈阳性的14名儿童中，未检测到“丝状舞蹈体征”。尽管淋巴闪烁显像显示入组儿童中有82％的儿童淋巴结和淋巴管受损，但在约67％的儿童中，经过24个月的随访，这种病理状况明显减轻。这些结果表明，由“消除淋巴丝虫病全球计划”进行的大规模药物管理中使用的药物方案能够逆转亚临床淋巴损伤，并且除了阻断流行地区的传播外，还可以提供其他益处。提出并讨论了这些发现的含义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号