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首页> 外文期刊>Journal of the mechanical behavior of biomedical materials >Transient stiffening of cartilage during joint articulation: A microindentation study
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Transient stiffening of cartilage during joint articulation: A microindentation study

机译：关节关节过程中软骨的瞬态加强：微观化研究

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As a mechanoactive tissue, articular cartilage undergoes compression and shear on a daily basis. With the advent of high resolution and sensitive mechanical testing methods, such as micro- and nanoindentation, it has become possible to assess changes in small-scale mechanical properties due to compression and shear of the tissue. However, investigations on the changes of these properties before and after joint articulation have been limited. To simulate articular loading of cartilage in the context of human gait, a previously developed bioreactor system was used. Immediately after bioreactor testing, the stiffness was measured using microindentation. Specifically, we investigated whether the mechanical response of the tissue was transient or permanent, dependent on counterface material, and an effect limited to the superficial zone of cartilage. We found that cartilage surface stiffness increases immediately after articular loading and returns to baseline values within 3 hr. Cartilage-on-cartilage stiffening was found to be higher compared to both alumina- and cobalt chromium-on-cartilage stiffening, which were not significantly different from each other. This stiffening response was found to be unique to the superficial zone, as articular loading on cartilage with the superficial zone removed showed no changes in stiffness. The findings of this study suggest that the cartilage superficial zone may adapt its stiffness as a response to articular loading. As the superficial zone is often compromised during the course of osteoarthritic disease, this finding is of clinical relevance, suggesting that the load-bearing function deteriorates over time.
机译：作为一种机械活动组织，关节软骨每天都会受到压缩和剪切。随着高分辨率和灵敏的机械测试方法的出现，如显微和纳米压痕，评估组织压缩和剪切引起的小规模机械性能变化已成为可能。然而，关于关节活动前后这些特性变化的研究有限。为了模拟人体步态下软骨的关节负荷，使用了先前开发的生物反应器系统。在生物反应器测试后，立即使用显微压痕测量硬度。具体来说，我们研究了组织的机械反应是暂时的还是永久性的，取决于反表面材料，以及仅限于软骨表面区域的影响。我们发现关节负荷后软骨表面硬度立即增加，并在3小时内恢复到基线值。与氧化铝和钴铬对软骨硬化的影响相比，软骨对软骨硬化的影响更大，两者之间没有显著差异。这种硬化反应被发现是浅表区特有的，因为去除浅表区后软骨上的关节负荷显示硬度没有变化。这项研究的结果表明，软骨表面区域可能会调整其刚度，作为对关节负荷的反应。由于在骨关节炎疾病过程中，浅表区往往受到损害，这一发现具有临床意义，表明承重功能随着时间的推移而恶化。

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