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首页> 外文期刊>Osteoarthritis and cartilage >Cartilage shear dynamics during tibio-femoral articulation: effect of acute joint injury and tribosupplementation on synovial fluid lubrication.
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Cartilage shear dynamics during tibio-femoral articulation: effect of acute joint injury and tribosupplementation on synovial fluid lubrication.

机译：胫股关节运动中的软骨剪切动力学：急性关节损伤和摩擦补充对滑液润滑的影响。

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OBJECTIVE: To determine the effects of acute injury and tribosupplementation by hyaluronan (HA) on synovial fluid (SF) modulation of cartilage shear during tibio-femoral articulation. METHODS: Human osteochondral blocks from the lateral femoral condyle (LFC) and tibial plateau (LTP) were apposed, compressed 13%, and subjected to sliding under video microscopy. Tests were conducted with equine SF from normal joints (NL-SF), SF from acutely injured joints (AI-SF), and AI-SF to which HA was added (AI-SF+HA). Local and overall shear strain (E(xz)) and the lateral displacement (Deltax) at which E(xz) reached 50% of peak values (Deltax(1/2)) were determined. RESULTS: During articulation, LFC and LTP cartilage E(xz) increased with Deltax and peaked when surfaces slid, with peak E(xz) being maintained during sliding. With AI-SF as lubricant, surface and overall Deltax(1/2) were approximately 40% and approximately 20% higher, respectively, than values with NL-SF and AI-SF+HA as lubricant. Also, peak E(xz) was markedly higher with AI-SF as lubricant than with NL-SF as lubricant, both near the surface (approximately 80%) and overall (50-200%). Following HA supplementation to AI-SF, E(xz) was reduced from values with AI-SF alone by 30-50% near the surface and 20-30% overall. Magnitudes of surface and overall E(xz) were markedly (approximately 50 to 80%) higher in LTP cartilage than LFC cartilage for all lubricants. CONCLUSION: Acute injury impairs SF function, elevating cartilage E(xz) markedly during tibio-femoral articulation; such elevated E(xz) may contribute to post-injury associated cartilage degeneration. Since HA partially restores the function of AI-SF, as indicated by E(xz), tribosupplements may be beneficial in modulating normal cartilage homeostasis.
机译：目的：探讨透明质酸（HA）对胫股骨关节运动时滑膜液（SF）调节软骨剪切的急性损伤和摩擦的影响。方法：将来自股骨外侧dy（LFC）和胫骨平台（LTP）的人骨软骨阻滞放置，压缩13％，并在视频显微镜下滑动。使用来自正常关节的马SF（NL-SF），来自严重受伤关节的马SF（AI-SF）和添加了HA的AI-SF（AI-SF + HA）进行测试。确定了局部和整体剪切应变（E（xz））以及E（xz）达到峰值的50％（Deltax（1/2））时的横向位移（Deltax）。结果：在关节运动过程中，LFC和LTP软骨E（xz）随着Deltax的增加而增加，并且在表面滑动时达到峰值，并且在滑动过程中保持峰值E（xz）。使用AI-SF作为润滑剂，表面和总体Deltax（1/2）分别比使用NL-SF和AI-SF + HA作为润滑剂的值高约40％和约20％。同样，在表面附近（大约80％）和整体（50-200％），使用AI-SF作为润滑剂的峰值E（xz）明显高于使用NL-SF作为润滑剂的峰值。 HA补充AI-SF后，E（xz）与单独AI-SF相比降低了30-50％（靠近表面）和20-30％（整体）。对于所有润滑剂，LTP软骨的表面和整体E（xz）的幅度均明显高于LFC软骨（约50％至80％）。结论：急性损伤会削弱SF功能，在胫股关节活动时明显升高软骨E（xz）;这种升高的E（xz）可能会导致损伤后相关的软骨变性。如E（xz）所示，由于HA能部分恢复AI-SF的功能，因此，补充糖可能有益于调节正常的软骨稳态。

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