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首页> 外文期刊>Journal of the mechanical behavior of biomedical materials >Mechanical and structural properties of different types of human aortic atherosclerotic plaques
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Mechanical and structural properties of different types of human aortic atherosclerotic plaques

机译：不同类型的人主动脉动脉粥样硬化斑块的机械和结构性

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摘要

Atherosclerotic plaques are characterized by structural heterogeneity affecting aortic behaviour under mechanical loading. There is evidence of direct connections between the structural plaque arrangement and the risk of plaque rupture. As a consequence of aortic plaque rupture, plaque components are transferred by the bloodstream to smaller vessels, resulting in acute cardiovascular events with a poor prognosis, such as heart attacks or strokes. Hence, evaluation of the composition, structure, and biochemical profile of atherosclerotic plaques seems to be of great importance to assess the properties of a mechanically induced failure, indicating the strength and rupture vulnerability of plaque. The main goal of the research was to determine experimentally under uniaxial loading the mechanical properties of different types of the human abdominal aorta and human aortic atherosclerotic plaques identified based on vibrational spectra (ATR-FTIR and FT-Raman spectroscopy) analysis and validated by histological staining. The potential of spectroscopic techniques as a useful histopathological tool was demonstrated. Three types of atherosclerotic plaques - predominantly calcified (APC), lipid (APL), and fibrotic (APF) - were distinguished and confirmed by histopathological examinations. Compared to the normal aorta, fibrotic plaques were stiffer (median of EH for circumferential and axial directions, respectively: 8.15 MPa and 6.56 MPa) and stronger (median of sigma(M) for APLc = 1.57 MPa and APLa = 1.64 MPa), lipidic plaques were the weakest (median of sigma M for APLc = 0.76 MPa and APLa = 0.51 MPa), and calcified plaques were the stiffest (median of E-H for circumferential and axial directions, respectively: 13.23 MPa and 6.67 MPa). Therefore, plaques detected as predominantly lipid and calcified are most prone to rupture; however, the failure process reflected by the simplification of the stress-stretch characteristics seems to vary depending on the plaque composition.
机译：动脉粥样硬化斑块的特点是结构异质性影响机械负荷下的主动脉行为。有证据表明，结构性斑块排列与斑块破裂风险之间存在直接联系。由于主动脉斑块破裂，斑块成分通过血流转移到较小的血管，导致急性心血管事件，预后不良，如心脏病发作或中风。因此，评估动脉粥样硬化斑块的组成、结构和生化特征对于评估机械诱发失效的性质、指示斑块的强度和破裂脆弱性似乎非常重要。该研究的主要目的是在单轴载荷下，通过振动光谱（ATR-FTIR和FT-Raman光谱）分析和组织学染色验证，通过实验确定不同类型的人类腹主动脉和人类主动脉粥样硬化斑块的机械性能。光谱技术作为一种有用的组织病理学工具的潜力得到了证明。三种类型的动脉粥样硬化斑块-主要钙化（APC）、脂质（APL）和纤维化（APF）-通过组织病理学检查进行区分和确认。与正常主动脉相比，纤维化斑块更硬（环向和轴向的EH中值分别为8.15 MPa和6.56 MPa），更强（APLc的sigma（M）中值为1.57 MPa，APLa=1.64 MPa），脂质斑块最弱（APLc的sigma M中值为0.76 MPa，APLa=0.51 MPa），钙化斑块的硬度最高（周向和轴向E-H的中值分别为13.23 MPa和6.67 MPa）。因此，以脂质和钙化为主的斑块最容易破裂；然而，应力拉伸特征的简化所反映的破坏过程似乎因菌斑成分而异。

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