...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of the Indian Chemical Society >Status of urinary porphyrins and inverse correlation of porphyrins with serum B vitamins in arsenic endemic area of West Bengal, India
【24h】

Status of urinary porphyrins and inverse correlation of porphyrins with serum B vitamins in arsenic endemic area of West Bengal, India

机译：印度西孟加拉邦砷地方区血清B维生素卟啉尿素卟啉及逆相关性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chronic arsenic toxicity through drinking water is still one of the major problems across the world. Bangladesh and India (particularly the state of West Bengal) are the worst affected countries with such problem. Millions of people all over the world are affected by arsenic related diseases. In our study, concentration of ground water arsenic, urine arsenic, hair arsenic and nail arsenic from adult individuals were measured from exposed areas of West Bengal, India respectively by flow injection atomic spectroscopy and transversely heated graphite atomiser techniques. Porphyrins, uroporphyrin III, heptacarboxyporphyrin I, hexacarboxyporphyrin I, pentacarboxyporphyrin I, coproporphyrin III in urine were analysed separately by HPLC using fluorescence detector as well as level of vitamin B-6, vitamin B-9 and vitamin B-12 were carried out in serum samples among the population in the selected area in North 24-Parganas, West Bengal, India. Concentration of uro III, hepta I, copro III and copro III/uro III were observed to increase irrespective of gender and also in total; whereas level of B vitamins were found to decrease with increase in exposure to arsenic contaminated drinking water from underground sources. The difference of vitamin B-6 (p 0.01) between the population exposed to 50 and 50 mu g/L arsenic in drinking water was found to be significant. Significant difference was also noticed in case of uro III (p 0.05), copro III (p 0.01) and copro III/uro III (p 0.05) between two exposure categories. This study demonstrated increasing tendency in urinary porphyrins as well as inverse relationships of serum B vitamins with increased water arsenic concentration.
机译：通过饮用水产生的慢性砷中毒仍然是世界范围内的主要问题之一。孟加拉国和印度（尤其是西孟加拉邦）是受此类问题影响最严重的国家。全世界数百万人受到砷相关疾病的影响。在我们的研究中，通过流动注射原子光谱法和横向加热石墨雾化技术，分别测量了印度西孟加拉邦暴露地区成年个体的地下水砷、尿砷、头发砷和指甲砷的浓度。采用高效液相色谱法，使用荧光检测器分别分析尿液中的卟啉、尿卟啉III、七羧基卟啉I、六羧基卟啉I、五羧基卟啉I、粪卟啉III，并在印度西孟加拉邦北24帕尔干纳选定地区的人群中检测血清中的维生素B-6、维生素B-9和维生素B-12水平。观察到，无论性别和总量，uro III、hepta I、copro III和copro III/uro III的浓度均增加；而B族维生素水平则随着暴露于受砷污染的地下水源饮用水的增加而降低。维生素B-6（p；0.01）在接触；50和；饮用水中50μg/L的砷含量显著。在两种暴露类别中，尿路三型（p；0.05）、copro III型（p；0.01）和copro III/uro III型（p；0.05）也存在显著差异。这项研究表明，尿卟啉有增加的趋势，血清B族维生素与水砷浓度增加呈反比关系。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号