...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Theoretical Biology >Imaging the living brain: An argument for ruthless reductionism from olfactory neurobiology
【24h】

Imaging the living brain: An argument for ruthless reductionism from olfactory neurobiology

机译：成像生活大脑：来自嗅觉神经生物学的无情减速症的争论

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Should theories of "higher-level" cognitive effects originate in "lower-level" molecular mechanisms? This paper supports reductionist explanations of sensory perception via molecular mechanisms in neurobiology. It shows that molecular and cellular mechanisms must constitute the material foundation to derive better theories and models for neuroscience. In support of "bottom-up theorizing", I explore the recent application of a new real-time molecular imaging technique (SCAPE microscopy) to mixture coding in olfaction. Seemingly emergent "higher-level" psychological effects in odor perception, irreducible to the physical stimulus, are linked back to underlying molecular mechanisms at the receptor level. The SCAPE study has notable theoretical impact. It provides a possible answer to the neurocomputational challenge in olfaction from combinatorial coding at the periphery: how does the brain discriminate different complex mixtures from widespread and overlapping receptor activation? The failure of previous reductionist structure-odor explanations is shown to reside in misconceptualizations of the critical causal elements involved. Causally fundamental features are not of parts independently of a mechanism. Components and their relevant features are units via their causal role within a mechanism. Here, new technologies allow revisiting our understanding of the ontology and levels of organization of a system. (C) 2020 Elsevier Ltd. All rights reserved.
机译：“高水平”认知效应的理论应该起源于“低水平”分子机制吗？本文支持神经生物学中通过分子机制对感觉知觉的还原论解释。这表明分子和细胞机制必须为神经科学提供更好的理论和模型的物质基础。为了支持“自下而上的理论”，我探索了一种新的实时分子成像技术（SCAPE显微镜）在嗅觉混合编码中的最新应用。气味感知中似乎出现的“更高层次”的心理效应，与物理刺激无关，与受体水平的潜在分子机制有关。SCAPE研究具有显著的理论影响。它为嗅觉的神经计算挑战提供了一个可能的答案：大脑如何区分不同复杂混合物与广泛重叠的受体激活？以往的还原论结构解释的失败在于对所涉及的关键因果要素的误解。因果基本特征不是独立于机制的部分。组件及其相关特征通过其在机制中的因果作用而成为单元。在这里，新技术允许我们重新理解系统的本体和组织层次。（C） 2020爱思唯尔有限公司版权所有。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号