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首页> 外文期刊>Journal of toxicology and environmental health, Part B. Critical reviews >Investigating palygorskite's role in the development of mesothelioma in southern Nevada: Insights into fiber-induced carcinogenicity
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Investigating palygorskite's role in the development of mesothelioma in southern Nevada: Insights into fiber-induced carcinogenicity

机译：调查帕莱戈斯斯坦特在内华达州南部间皮瘤发展中的作用：纤维诱发的致癌性见解

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摘要

Similar to asbestos fibers, nonregulated mineral fibers can cause malignant mesothelioma (MM). Recently, increased proportions of women and young individuals with MM were identified in southern Nevada, suggesting that environmental exposure to carcinogenic fibers was causing the development of MM. Palygorskite, a fibrous silicate mineral with a history of possible carcinogenicity, is abundant in southern Nevada. In this study, our aim was to determine whether palygorskite was contributing to the development of MM in southern Nevada. While palygorskite, in vitro, displayed some cytotoxicity toward primary human mesothelial (HM) cells and reduced their viability, the effects were roughly half of those observed when using similar amounts of crocidolite asbestos. No Balb/c (0/19) or MexTAg (0/18) mice injected with palygorskite developed MM, while 3/16 Balb/c and 13/14 MexTAg mice injected with crocidolite did. Lack of MM development was associated with a decreased acute inflammatory response, as injection of palygorskite resulted in lower percentages of macrophages (p=.006) and neutrophils (p=.02) in the peritoneal cavity 3 d after exposure compared to injection of crocidolite. Additionally, compared to mice injected with crocidolite, palygorskite-injected mice had lower percentages of M2 (tumor-promoting) macrophages (p=.008) in their peritoneal cavities when exposed to fiber for several weeks. Our study indicates that palygorskite found in the environment in southern Nevada does not cause MM in mice, seemingly because palygorskite, in vivo, fails to elicit inflammation that is associated with MM development. Therefore, palygorskite is not a likely contributor to the MM cases observed in southern Nevada.
机译：与石棉纤维类似，不受调节的矿物纤维可导致恶性间皮瘤（MM）。最近，内华达州南部发现患有MM的女性和年轻人比例增加，这表明环境暴露于致癌纤维导致了MM的发展。坡缕石是一种纤维状硅酸盐矿物，有可能致癌的历史，在内华达州南部十分丰富。在这项研究中，我们的目的是确定坡缕石是否有助于内华达州南部MM的发展。虽然坡缕石在体外对原代人间皮细胞（HM）显示出一定的细胞毒性，并降低了其活性，但其效果大约是使用类似量青石棉时观察到的效果的一半。注射坡缕石的Balb/c（0/19）或MexTAg（0/18）小鼠均未出现MM，而注射青石棉的Balb/c和MexTAg小鼠分别为3/16和13/14。与注射青石棉相比，注射坡缕石后3d腹腔巨噬细胞（p=0.006）和中性粒细胞（p=0.02）的百分比较低，因此MM发育的缺乏与急性炎症反应的降低有关。此外，与注射青石棉的小鼠相比，注射坡缕石的小鼠在暴露于纤维数周后，其腹腔内M2（促瘤）巨噬细胞的百分比较低（p=0.008）。我们的研究表明，在内华达州南部环境中发现的坡缕石不会在小鼠体内引起MM，似乎是因为坡缕石在体内不能引起与MM发展相关的炎症。因此，坡缕石不是内华达州南部观察到的MM病例的可能原因。

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