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首页> 外文期刊>Journal of women’s health >The Masquerading, Masculinizing Tumor: A Case Report and Review of the Literature
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The Masquerading, Masculinizing Tumor: A Case Report and Review of the Literature

机译：伪装，男性化肿瘤：对文献的案例报告和审查

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摘要

Androgen-producing tumors in women are rare neoplasms that can cause secondary virilizing characteristics. Of patients presenting with symptoms of hyperandrogenism, these tumors are found in similar to 0.2% of cases. Androgen-producing tumors can arise from the ovary or the adrenal gland. Those arising from the ovary are rare, accounting for <5% of all ovarian tumors. This case presents a hilar Leydig cell tumor of the ovary, which resulted in secondary virilization of a 45-year-old female 2 months after cessation of combined oral contraceptives (COC). Laboratory findings showed markedly elevated total and free testosterone concentrations with normal dehydroepiandrosterone sulfate, however neither pelvic ultrasound nor magnetic resonance imaging demonstrated any masses. Venous sampling under fluoroscopy revealed supraphysiologic testosterone concentrations from the right ovarian vein suggesting the source. The patient underwent bilateral salpingo-oophorectomy revealing a 1.3 cm hilar cell tumor of the right ovary. This article reviews the clinical features, diagnosis, and treatment of hilar Leydig cell tumors and describes the long-term complications of supraphysiologic testosterone levels. As the tumor presented after cessation of COC, we also review the mechanisms by which COC might suppress supraphysiologic androgen levels and mask the secondary virilizing effects of androgen-producing tumors.
机译：女性体内产生雄激素的肿瘤是一种罕见的肿瘤，可引起继发性男性化特征。在出现高雄激素血症症状的患者中，这些肿瘤的发生率与0.2%的病例相似。产生雄激素的肿瘤可以发生在卵巢或肾上腺。卵巢肿瘤很少见，占所有卵巢肿瘤的<5%。本病例为卵巢肺门间质细胞瘤，导致一名45岁女性在停用联合口服避孕药（COC）2个月后再次男性化。实验室检查结果显示，正常硫酸脱氢表雄酮的总睾酮和游离睾酮浓度显著升高，但盆腔超声和磁共振成像均未显示任何肿块。荧光透视下的静脉取样显示，右卵巢静脉的超生理睾酮浓度提示来源。患者接受了双侧输卵管卵巢切除术，发现右侧卵巢有1.3厘米的门细胞肿瘤。本文综述了肺门间质细胞肿瘤的临床特征、诊断和治疗，并描述了超生理睾酮水平的长期并发症。由于COC停止后出现的肿瘤，我们还回顾了COC抑制超生理雄激素水平和掩盖雄激素产生肿瘤的继发性男性化效应的机制。

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