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首页> 外文期刊>Annals of Tropical Paediatrics >Emergence of multi-drug-resistant Acinetobacter anitratus species in neonatal and paediatric intensive care units in a developing country: concern about antimicrobial policies.
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Emergence of multi-drug-resistant Acinetobacter anitratus species in neonatal and paediatric intensive care units in a developing country: concern about antimicrobial policies.

机译：发展中国家新生儿和儿科重症监护病房中出现多种耐药性的苯胺不动杆菌种：对抗菌政策的关注。

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摘要

Antimicrobial abuse is a serious risk factor for the emergence of multi-drug-resistant (MDR) pathogens. We report on the emergence of multi-drug-resistant Acinetobacter anitratus species over two 8-week periods in 1999 in the neonatal and paediatric intensive care units (NICU and PICU) of King Edward VII Hospital, Durban, South Africa. The source, transmission dynamics, microbiological evaluations, antibiotic utilization patterns and outcome were evaluated. MDR Acinetobacter anitratus was isolated from different body sites in 23 infants less than 2 months of age, 18 in the PICU and five in the NICU. The mortality was 56.5% and two survivors required re-admission. Ten of the 23 cases had entered the ICU with MDR Acinetobacter anitratus. Eleven of the study infants had received broad-spectrum antimicrobial agents before entering the ICU, while all infants with nosocomially acquired MDR Acinetobacter anitratus had received broad-spectrum antimicrobial agents. All the surgical cases with MDR Acinetobacter anitratus died. Microbiological data from both ICUs for 1999 indicated that gram-negative bacteria accounted for two-thirds of isolates, Acinetobacter anitratus and Klebsiella pneumoniae accounting for 33% and 27% of the isolates, respectively. Only 53% and 57% of all Acinetobacter spp isolates were susceptible to piperacillin/tazobactam and carbepenems, respectively. MDR Acinetobacter anitratus is an emerging problem to which antimicrobial abuse contributes.
机译：抗菌药物滥用是多重耐药性（MDR）病原体出现的严重风险因素。我们报告了1999年在南非德班国王爱德华七世医院的新生儿和儿科重症监护病房（NICU和PICU）中出现的两个8周周期中出现的多种耐药苯胺不动杆菌种。对来源，传播动力学，微生物学评估，抗生素利用模式和结果进行了评估。在23个小于2个月的婴儿中从不同的身体部位分离出耐多药的不动杆菌，在PICU中有18例，在NICU中有5例。死亡率为56.5％，两名幸存者需要重新入院。 23例病例中有10例与MDR anitratus进入了ICU。进入ICU的研究婴儿中有11名已接受了广谱抗菌药物，而所有医院获得性耐多药耐药性苯胺不动杆菌的婴儿均已接受了广谱抗菌药物。耐多药耐药性不动杆菌的所有手术病例均死亡。来自两个ICU的1999年微生物学数据表明，革兰氏阴性菌占分离株的三分之二，苯胺不动杆菌和肺炎克雷伯菌分别占分离株的33％和27％。所有不动杆菌属菌株中分别只有53％和57％易受哌拉西林/他唑巴坦和碳青霉烯类药物的影响。耐多药苯胺不动杆菌是一个新出现的问题，抗生素滥用是造成这一问题的原因。

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