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Emerging Approaches to Functionalizing Cell Membrane-Coated Nanoparticles

机译：官能化细胞膜涂层纳米粒子的新出现方法

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摘要

There has been significant interest in developing cell membrane-coated nanoparticles due to their unique abilities of biomimicry and biointerfacing. As the technology progresses, it becomes clear that the application of these nanoparticles can be drastically broadened if additional functions beyond those derived from the natural cell membranes can be integrated. Herein, we summarize the most recent advances in the functionalization of cell membrane-coated nanoparticles. In particular, we focus on emerging methods, including (1) lipid insertion, (2) membrane hybridization, (3) metabolic engineering, and (4) genetic modification. These approaches contribute diverse functions in a nondisruptive fashion while preserving the natural function of the cell membranes. They also improve on the multifunctional and multitasking ability of cell membrane-coated nanoparticles, making them more adaptive to the complexity of biological systems. We hope that these approaches will serve as inspiration for more strategies and innovations to advance cell membrane coating technology.
机译：由于细胞膜包裹的纳米颗粒具有独特的仿生和界面连接能力，因此人们对其进行了研究。随着技术的进步，很明显，如果能够整合天然细胞膜以外的其他功能，这些纳米颗粒的应用可以大大拓宽。在此，我们总结了细胞膜包覆纳米颗粒功能化的最新进展。我们特别关注新兴的方法，包括（1）脂质插入，（2）膜杂交，（3）代谢工程和（4）基因修饰。这些方法以无中断的方式提供多种功能，同时保留细胞膜的自然功能。它们还改善了细胞膜包覆纳米颗粒的多功能和多任务能力，使其更适应生物系统的复杂性。我们希望这些方法能为推进细胞膜包衣技术的更多策略和创新提供启发。

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  • 来源
    《Biochemistry》 |2021年第13期|共15页
  • 作者

    Xiangzhao Ai; Shuyan Wang; Yaou Duan; Qiangzhe Zhang; Maggie S. Chen; Weiwei Gao; Liangfang Zhang;

  • 作者单位

    Department of NanoEngineering Chemical Engineering Program and Moores Cancer Center University of California;

    Department of NanoEngineering Chemical Engineering Program and Moores Cancer Center University of California;

    Department of NanoEngineering Chemical Engineering Program and Moores Cancer Center University of California;

    Department of NanoEngineering Chemical Engineering Program and Moores Cancer Center University of California;

    Department of NanoEngineering Chemical Engineering Program and Moores Cancer Center University of California;

    Department of NanoEngineering Chemical Engineering Program and Moores Cancer Center University of California;

    Department of NanoEngineering Chemical Engineering Program and Moores Cancer Center University of California;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
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