A New and Highly Stable Cocrystal of Vitamin D3 for Use in Enhanced Food Supplements

Lídia  Bofill; Dafne  de Sande; Rafael  Barbas; Rafel  Prohens

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A New and Highly Stable Cocrystal of Vitamin D3 for Use in Enhanced Food Supplements

机译：一种用于增强的食品补充剂的一种新的和高度稳定的维生素D3

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A new cocrystal of Vitamin D_(3) (Cholecalciferol) and resorcinol has been discovered and characterized through experimental cocrystal screening. Its high stability has been studied against light, heat, and chemicals present in animal food premixes in order to develop a novel and alternative formulation to current microencapsulation approaches to protect Vitamin D_(3) from oxidation. Our results show that the new cocrystal is extremely stable and it can become the basis for very efficient formulations of Vitamin D_(3) which fulfills the stability requirements of industrial applications.

机译：发现了维生素D_3（胆钙化醇）和间苯二酚的新共晶，并通过实验共晶筛选对其进行了表征。为了开发一种新的替代配方，以保护维生素D_3免受氧化，对其在动物食品预混料中的光、热和化学物质的高稳定性进行了研究。我们的研究结果表明，新的共晶体非常稳定，可以成为非常有效的维生素D_3配方的基础，满足工业应用的稳定性要求。

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来源
《Crystal growth & design》 |2021年第3期|共6页
作者
Lídia Bofill; Dafne de Sande; Rafael Barbas; Rafel Prohens;
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作者单位

Center for Intelligent Research in Crystal Engineering S.L. Parc Científic de Barcelona Baldiri Reixac;

Unitat de Polimorfisme i Calorimetria Centres Científics i Tecnològics Universitat de Barcelona;

Unitat de Polimorfisme i Calorimetria Centres Científics i Tecnològics Universitat de Barcelona;

Center for Intelligent Research in Crystal Engineering S.L. Parc Científic de Barcelona Baldiri Reixac;

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正文语种 eng
中图分类晶体学;
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3. Vitamin D3 supplementation influences ovarian histomorphometry and follicular development in prepubertal albino rats [J] . Edmund Chidiebere Mbegbu, Ikechukwu Reginald Obidike 亚太生殖杂志（英文版） . 2020,第006期
4. Vitamin D3 supplementation influences ovarian histomorphometry and follicular development in prepubertal albino rats [J] . Edmund Chidiebere Mbegbu, Ikechukwu Reginald Obidike 亚太生殖杂志(英文版) . 2020,第006期
5. Selective monitoring of vitamin D2 and D3 supplementation with a highly specific 25-hydroxyvitamin D3 immunoassay with negligible cross-reactivity to 25-hydroxyvitamin D2. [J] . Li B, Byrjalsen I, Glendenning P Clinica chimica acta: International journal of clinical chemistry and applied molecular biology . 2009,第2期

机译：用高度特异性的25-羟基维生素D3免疫测定法选择性监测维生素D2和D3补充剂，与25-羟基维生素D2的交叉反应性可忽略不计。
6. Enhanced biological activity of 1alpha,25-dihydroxy-20-epi-vitamin D3, the C-20 epimer of 1alpha,25-dihydroxyvitamin D3, is in part due to its metabolism into stable intermediary metabolites with significant biological activity. [J] . Siu Caldera-ML, Sekimoto H, Peleg S, The Journal of Steroid Biochemistry and Molecular Biology . 1999,第3a4期

机译：1alpha，25-dihydroxy-20-epi-vitamin D3（1alpha，25-dihydroxyvitamin D3的C-20差向异构体）的增强的生物活性部分是由于其代谢为具有重要生物学活性的稳定的中间代谢产物。
7. Enhancement of vitamin D metabolites in the eye following vitamin D3 supplementation and UV-B irradiation [J] . LinY., UbelsJ.L., SchotanusM.P., Current Eye Research . 2012,第10期

机译：补充维生素D3和UV-B照射后眼睛中维生素D代谢物的增强
8. Daily supplementation with 800 IU of vitamin D3insufficient for achievement of vitamin Dadequacy in elderly hip fracture patients [C] . E. Segal, C. Zinman, B. Raz, International Symposium on Nutritional Aspects of Osteoporosis . 2007

机译：每日补充维生素D3的800 IU，以实现老年髋关节骨折患者的维生素Dadequacy
9. The effect of vitamin D2, vitamin D3 or vitamin D2 in mushroom powder supplements on broad gene expression in human white blood cells. [D] . Feigert, Caroline Elizabeth. 2014

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机译：一项随机交叉研究估计补充维生素D3后食物对25-羟维生素D3血清水平的影响
11. A Randomised, Cross-Over Study to Estimate the Influence of Food on the 25-Hydroxyvitamin D3 Serum Level after Vitamin D3 Supplementation [O] . Etienne Cavalier, Bernard Jandrain, Monte Coffiner, 2016

机译：一项随机交叉研究评估食物对维生素D3补充后25-羟维生素D3血清水平的影响
12. Vitamin D3 and Vitamin D3 Analogs as Protectants Against the Cardiotoxicity of Chemotherapeutic Agents Utilized in the Treatment of Breast Cancer [R] . Gewirtz, D. A. 2010

机译：维生素D3和维生素D3类似物作为防治化疗药物心脏毒性的保护剂用于治疗乳腺癌

A New and Highly Stable Cocrystal of Vitamin D3 for Use in Enhanced Food Supplements

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